Targeting nonsense-mediated mRNA decay in colorectal cancers with microsatellite instability

Nonsense-mediated mRNA decay (NMD) is responsible for the degradation of mRNAs with a premature termination codon (PTC). The role of this system in cancer is still quite poorly understood. In the present study, we evaluated the functional consequences of NMD activity in a subgroup of colorectal canc...

Descripción completa

Detalles Bibliográficos
Autores principales: Bokhari, A’dem, Jonchere, Vincent, Lagrange, Anaïs, Bertrand, Romane, Svrcek, Magali, Marisa, Laetitia, Buhard, Olivier, Greene, Malorie, Demidova, Anastasia, Jia, Jieshuang, Adriaenssens, Eric, Chassat, Thierry, Biard, Denis S., Flejou, Jean-François, Lejeune, Fabrice, Duval, Alex, Collura, Ada
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6143633/
https://www.ncbi.nlm.nih.gov/pubmed/30228267
http://dx.doi.org/10.1038/s41389-018-0079-x

Ejemplares similares

Ejemplares similares