Cargando…

High-Frequency, Functional HIV-Specific T-Follicular Helper and Regulatory Cells Are Present Within Germinal Centers in Children but Not Adults

Broadly neutralizing antibodies (bnAbs) against HIV-1 are an effective means of preventing transmission. To better understand the mechanisms by which HIV-specific bnAbs naturally develop, we investigated blood and lymphoid tissue in pediatric infection, since potent bnAbs develop with greater freque...

Descripción completa

Detalles Bibliográficos
Autores principales:	Roider, Julia, Maehara, Takashi, Ngoepe, Abigail, Ramsuran, Duran, Muenchhoff, Maximilian, Adland, Emily, Aicher, Toby, Kazer, Samuel W., Jooste, Pieter, Karim, Farina, Kuhn, Warren, Shalek, Alex K., Ndung'u, Thumbi, Morris, Lynn, Moore, Penny L., Pillai, Shiv, Kløverpris, Henrik, Goulder, Philip, Leslie, Alasdair
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2018
Materias:	Immunology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6143653/ https://www.ncbi.nlm.nih.gov/pubmed/30258437 http://dx.doi.org/10.3389/fimmu.2018.01975

Ejemplares similares

Increased Regulatory T-Cell Activity and Enhanced T-Cell Homeostatic Signaling in Slow Progressing HIV-infected Children
por: Roider, Julia, et al.
Publicado: (2019)

Innate Lymphoid Cell Activation and Sustained Depletion in Blood and Tissue of Children Infected with HIV from Birth Despite Antiretroviral Therapy
por: Singh, Alveera, et al.
Publicado: (2020)

Differential Pathogen-Specific Immune Reconstitution in Antiretroviral Therapy-Treated Human Immunodeficiency Virus-Infected Children
por: Muenchhoff, Maximilian, et al.
Publicado: (2019)

Plasma IL-5 but Not CXCL13 Correlates With Neutralization Breadth in HIV-Infected Children
por: Roider, Julia, et al.
Publicado: (2019)

Distinct Immunoglobulin Fc Glycosylation Patterns Are Associated with Disease Nonprogression and Broadly Neutralizing Antibody Responses in Children with HIV Infection
por: Muenchhoff, M., et al.
Publicado: (2020)

Slow progression of pediatric HIV associates with early CD8(+) T cell PD-1 expression and a stem-like phenotype
por: Vieira, Vinicius, et al.
Publicado: (2023)

Unbiased Profiling Reveals Compartmentalization of Unconventional T-Cells Within the Intestinal Mucosa Irrespective of HIV Infection
por: Magnoumba, Magalli, et al.
Publicado: (2020)

Cytomegalovirus-Mediated T Cell Receptor Repertoire Perturbation Is Present in Early Life
por: Attaf, Meriem, et al.
Publicado: (2020)

Corrigendum: Cytomegalovirus-Mediated T Cell Receptor Repertoire Perturbation Is Present in Early Life
por: Attaf, Meriem, et al.
Publicado: (2020)

HIV-1 Subtype C-Infected Children with Exceptional Neutralization Breadth Exhibit Polyclonal Responses Targeting Known Epitopes
por: Ditse, Zanele, et al.
Publicado: (2018)

Paediatric non-progression following grandmother-to-child HIV transmission
por: Tsai, M.-H., et al.
Publicado: (2016)

Major TCR Repertoire Perturbation by Immunodominant HLA-B(*)44:03-Restricted CMV-Specific T Cells
por: Attaf, Meriem, et al.
Publicado: (2018)

Evaluation of the NucliSens EasyQ v2.0 Assay in Comparison with the Roche Amplicor v1.5 and the Roche CAP/CTM HIV-1 Test v2.0 in Quantification of C-Clade HIV-1 in Plasma
por: Muenchhoff, Maximilian, et al.
Publicado: (2014)

Malnutrition in HIV-Infected Children Is an Indicator of Severe Disease with an Impaired Response to Antiretroviral Therapy
por: Muenchhoff, Maximilian, et al.
Publicado: (2018)

HIV specific CD8(+) T(RM)-like cells in tonsils express exhaustive signatures in the absence of natural HIV control
por: Fardoos, Rabiah, et al.
Publicado: (2022)

An HLA-I signature favouring KIR-educated Natural Killer cells mediates immune control of HIV in children and contrasts with the HLA-B-restricted CD8+ T-cell-mediated immune control in adults
por: Vieira, Vinicius A., et al.
Publicado: (2021)

Sex Differences in Antiretroviral Therapy Initiation in Pediatric HIV Infection
por: Mori, Masahiko, et al.
Publicado: (2015)

Early Initiation of Antiretroviral Therapy Following In Utero HIV Infection Is Associated With Low Viral Reservoirs but Other Factors Determine Viral Rebound
por: Millar, Jane R, et al.
Publicado: (2021)

Immunodominant cytomegalovirus-specific CD8+ T-cell responses in sub-Saharan African populations
por: Malik, Amna, et al.
Publicado: (2017)

The KT Jeang retrovirology prize 2023: Thumbi Ndung’u
por: Ndung’u, Thumbi
Publicado: (2023)

Discordant Impact of HLA on Viral Replicative Capacity and Disease Progression in Pediatric and Adult HIV Infection
por: Adland, Emily, et al.
Publicado: (2015)

Nef-Specific CD8+ T Cell Responses Contribute to HIV-1 Immune Control
por: Adland, Emily, et al.
Publicado: (2013)

Recovery of effective HIV-specific CD4(+) T-cell activity following antiretroviral therapy in paediatric infection requires sustained suppression of viraemia
por: Adland, Emily, et al.
Publicado: (2018)

Investigating neutrophil cell death in TB pathogenesis
por: Fisher, Kimone L, et al.
Publicado: (2022)

Integrated single-cell analysis of multicellular immune dynamics during hyperacute HIV-1 infection
por: Kazer, Samuel W., et al.
Publicado: (2020)

Role of HLA Adaptation in HIV Evolution
por: Kløverpris, Henrik N., et al.
Publicado: (2016)

Irreversible depletion of intestinal CD4(+) T cells is associated with T cell activation during chronic HIV infection
por: Asowata, Osaretin E., et al.
Publicado: (2021)

HIV-1 subtype C envelope characteristics associated with divergent rates of chronic disease progression
por: Archary, Derseree, et al.
Publicado: (2010)

Characterizing the epidemiology and interaction between HIV-1 and HBV co-infection in South Africa
por: Matthews, Philippa C, et al.
Publicado: (2014)

HIV skews the SARS-CoV-2 B cell response towards an extrafollicular maturation pathway
por: Krause, Robert, et al.
Publicado: (2022)

HIV-1 vaccine immunogen design strategies
por: Mann, Jaclyn K, et al.
Publicado: (2015)

The potential of lactoferrin, ovotransferrin and lysozyme as antiviral and immune-modulating agents in COVID-19
por: Mann, Jaclyn Kelly, et al.
Publicado: (2020)

PARV4 prevalence, phylogeny, immunology and coinfection with HIV, HBV and HCV in a multicentre African cohort
por: Sharp, Colin P., et al.
Publicado: (2017)

Prevalence and seasonality of common viral respiratory pathogens, including Cytomegalovirus in children, between 0–5 years of age in KwaZulu-Natal, an HIV endemic province in South Africa
por: Famoroti, Temitayo, et al.
Publicado: (2018)

Similar Antibody Responses Against Severe Acute Respiratory Syndrome Coronavirus 2 in Individuals Living Without and With Human Immunodeficiency Virus on Antiretroviral Therapy During the First South African Infection Wave
por: Snyman, Jumari, et al.
Publicado: (2021)

MR1-Restricted MAIT Cells From The Human Lung Mucosal Surface Have Distinct Phenotypic, Functional, and Transcriptomic Features That Are Preserved in HIV Infection
por: Khuzwayo, Sharon, et al.
Publicado: (2021)

Group 3 innate lymphoid cells mediate early protective immunity against tuberculosis
por: Ardain, Amanda, et al.
Publicado: (2019)

COVID-19 in Africa: preexisting immunity and HIV
por: Snyman, Jumari, et al.
Publicado: (2021)

Author Correction: Sex-specific innate immune selection of HIV-1 in utero is associated with increased female susceptibility to infection
por: Adland, Emily, et al.
Publicado: (2020)

Sex-specific innate immune selection of HIV-1 in utero is associated with increased female susceptibility to infection
por: Adland, Emily, et al.
Publicado: (2020)

Cannot write session to /tmp/vufind_sessions/sess_44pthcptbl49pmmh66kte135lv