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Fractalis: a scalable open-source service for platform-independent interactive visual analysis of biomedical data

BACKGROUND: Translational research platforms share the aim of promoting a deeper understanding of stored data by providing visualization and analysis tools for data exploration and hypothesis generation. However, such tools are usually platform bound and are not easily reusable by other systems. Fur...

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Detalles Bibliográficos
Autores principales: Herzinger, Sascha, Grouès, Valentin, Gu, Wei, Satagopam, Venkata, Banda, Peter, Trefois, Christophe, Schneider, Reinhard
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6143733/
https://www.ncbi.nlm.nih.gov/pubmed/30165440
http://dx.doi.org/10.1093/gigascience/giy109
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author Herzinger, Sascha
Grouès, Valentin
Gu, Wei
Satagopam, Venkata
Banda, Peter
Trefois, Christophe
Schneider, Reinhard
author_facet Herzinger, Sascha
Grouès, Valentin
Gu, Wei
Satagopam, Venkata
Banda, Peter
Trefois, Christophe
Schneider, Reinhard
author_sort Herzinger, Sascha
collection PubMed
description BACKGROUND: Translational research platforms share the aim of promoting a deeper understanding of stored data by providing visualization and analysis tools for data exploration and hypothesis generation. However, such tools are usually platform bound and are not easily reusable by other systems. Furthermore, they rarely address access restriction issues when direct data transfer is not permitted. In this article, we present an analytical service that works in tandem with a visualization library to address these problems. FINDINGS: Using a combination of existing technologies and a platform-specific data abstraction layer, we developed a service that is capable of providing existing web-based data warehouses and repositories with platform-independent visual analytical capabilities. The design of this service also allows for federated data analysis by eliminating the need to move the data directly to the researcher. Instead, all operations are based on statistics and interactive charts without direct access to the dataset. CONCLUSIONS: The software presented in this article has a potential to help translational researchers achieve a better understanding of a given dataset and quickly generate new hypotheses. Furthermore, it provides a framework that can be used to share and reuse explorative analysis tools within the community.
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spelling pubmed-61437332018-09-24 Fractalis: a scalable open-source service for platform-independent interactive visual analysis of biomedical data Herzinger, Sascha Grouès, Valentin Gu, Wei Satagopam, Venkata Banda, Peter Trefois, Christophe Schneider, Reinhard Gigascience Technical Note BACKGROUND: Translational research platforms share the aim of promoting a deeper understanding of stored data by providing visualization and analysis tools for data exploration and hypothesis generation. However, such tools are usually platform bound and are not easily reusable by other systems. Furthermore, they rarely address access restriction issues when direct data transfer is not permitted. In this article, we present an analytical service that works in tandem with a visualization library to address these problems. FINDINGS: Using a combination of existing technologies and a platform-specific data abstraction layer, we developed a service that is capable of providing existing web-based data warehouses and repositories with platform-independent visual analytical capabilities. The design of this service also allows for federated data analysis by eliminating the need to move the data directly to the researcher. Instead, all operations are based on statistics and interactive charts without direct access to the dataset. CONCLUSIONS: The software presented in this article has a potential to help translational researchers achieve a better understanding of a given dataset and quickly generate new hypotheses. Furthermore, it provides a framework that can be used to share and reuse explorative analysis tools within the community. Oxford University Press 2018-08-27 /pmc/articles/PMC6143733/ /pubmed/30165440 http://dx.doi.org/10.1093/gigascience/giy109 Text en © The Author(s) 2018. Published by Oxford University Press. http://creativecommons.org/licenses/by/4.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Technical Note
Herzinger, Sascha
Grouès, Valentin
Gu, Wei
Satagopam, Venkata
Banda, Peter
Trefois, Christophe
Schneider, Reinhard
Fractalis: a scalable open-source service for platform-independent interactive visual analysis of biomedical data
title Fractalis: a scalable open-source service for platform-independent interactive visual analysis of biomedical data
title_full Fractalis: a scalable open-source service for platform-independent interactive visual analysis of biomedical data
title_fullStr Fractalis: a scalable open-source service for platform-independent interactive visual analysis of biomedical data
title_full_unstemmed Fractalis: a scalable open-source service for platform-independent interactive visual analysis of biomedical data
title_short Fractalis: a scalable open-source service for platform-independent interactive visual analysis of biomedical data
title_sort fractalis: a scalable open-source service for platform-independent interactive visual analysis of biomedical data
topic Technical Note
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6143733/
https://www.ncbi.nlm.nih.gov/pubmed/30165440
http://dx.doi.org/10.1093/gigascience/giy109
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