Systematic bias between blinded independent central review and local assessment: literature review and analyses of 76 phase III randomised controlled trials in 45 688 patients with advanced solid tumour

OBJECTIVE: Unbiased assessment of tumour response is crucial in randomised controlled trials (RCTs). Blinded independent central review is usually used as a supplemental or monitor to local assessment but is costly. The aim of this study is to investigate whether systematic bias existed in RCTs by c...

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Detalles Bibliográficos
Autores principales: Zhang, Jianrong, Zhang, Yiyin, Tang, Shiyan, Jiang, Long, He, Qihua, Hamblin, Lindsey Tristine, He, Jiaxi, Xu, Zhiheng, Wu, Jieyu, Chen, Yaoqi, Liang, Hengrui, Chen, Difei, Huang, Yu, Wang, Xinyu, Deng, Kexin, Jiang, Shuhan, Zhou, Jiaqing, Xu, Jiaxuan, Chen, Xuanzuo, Liang, Wenhua, He, Jianxing
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BMJ Publishing Group 2018
Materias:
Research Methods
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6144327/
https://www.ncbi.nlm.nih.gov/pubmed/30206071
http://dx.doi.org/10.1136/bmjopen-2017-017240

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