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Group cognitive remediation therapy for adults with obesity prior to behavioural weight loss treatment: study protocol for a randomised controlled superiority study (CRT study)
INTRODUCTION: Individuals with obesity show deficits in executive functioning which have been implicated in decreased weight loss outcome. Preliminary evidence suggests that cognitive remediation therapy (CRT) improves executive functioning and weight loss in obesity. However, confirmatory support,...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BMJ Publishing Group
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6144388/ https://www.ncbi.nlm.nih.gov/pubmed/30224391 http://dx.doi.org/10.1136/bmjopen-2018-022616 |
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author | Hilbert, Anja Blume, Marie Petroff, David Neuhaus, Petra Smith, Evelyn Hay, Phillipa J Hübner, Claudia |
author_facet | Hilbert, Anja Blume, Marie Petroff, David Neuhaus, Petra Smith, Evelyn Hay, Phillipa J Hübner, Claudia |
author_sort | Hilbert, Anja |
collection | PubMed |
description | INTRODUCTION: Individuals with obesity show deficits in executive functioning which have been implicated in decreased weight loss outcome. Preliminary evidence suggests that cognitive remediation therapy (CRT) improves executive functioning and weight loss in obesity. However, confirmatory support, especially for pre-weight loss use, is lacking. The CRT study aims at determining the efficacy of CRT versus no treatment control in patients with obesity before entering behavioural weight loss (BWL) treatment. It is hypothesised that individuals who receive CRT will show better weight loss outcome, improved executive functioning, greater weight loss-related behavioural changes and higher attendance of BWL treatment, 6 and 12 months after cessation of CRT. METHODS AND ANALYSIS: In a single-centre, assessor-blinded, randomised, two-armed parallel-group superiority trial, 260 adults with body mass index ≥35.0 kg/m(2) are centrally randomised to 8-week group-based CRT versus no treatment, before entering BWL treatment. Primary outcome is the amount of weight loss (%) at 6-month follow-up, compared with pre-treatment, derived from measured body weight. Secondary outcomes include improvement in executive functioning post-treatment and in weight loss-related behaviour, mental and physical health, and attendance to BWL treatment at 6-month and 12-month follow-up. Maintenance of weight loss at 12-month follow-up will be determined. Mixed model analyses based on intent-to-treat will be used to compare the CRT and control groups with respect to differences in weight change between pre-treatment and 6-month follow-up. Similar models will be used for analysing 12-month follow-up data and secondary outcomes. Further analyses will include additional covariates to identify predictors of treatment outcome. ETHICS AND DISSEMINATION: The study was approved by the Ethical Committee of the University of Leipzig (256-15-13072015, version ‘Final 1.0 from 28 May 2015). The study results will be disseminated through peer-reviewed publications. TRIAL REGISTRATION NUMBER: DRKS00009333; Pre-results. |
format | Online Article Text |
id | pubmed-6144388 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2018 |
publisher | BMJ Publishing Group |
record_format | MEDLINE/PubMed |
spelling | pubmed-61443882018-09-21 Group cognitive remediation therapy for adults with obesity prior to behavioural weight loss treatment: study protocol for a randomised controlled superiority study (CRT study) Hilbert, Anja Blume, Marie Petroff, David Neuhaus, Petra Smith, Evelyn Hay, Phillipa J Hübner, Claudia BMJ Open Nutrition and Metabolism INTRODUCTION: Individuals with obesity show deficits in executive functioning which have been implicated in decreased weight loss outcome. Preliminary evidence suggests that cognitive remediation therapy (CRT) improves executive functioning and weight loss in obesity. However, confirmatory support, especially for pre-weight loss use, is lacking. The CRT study aims at determining the efficacy of CRT versus no treatment control in patients with obesity before entering behavioural weight loss (BWL) treatment. It is hypothesised that individuals who receive CRT will show better weight loss outcome, improved executive functioning, greater weight loss-related behavioural changes and higher attendance of BWL treatment, 6 and 12 months after cessation of CRT. METHODS AND ANALYSIS: In a single-centre, assessor-blinded, randomised, two-armed parallel-group superiority trial, 260 adults with body mass index ≥35.0 kg/m(2) are centrally randomised to 8-week group-based CRT versus no treatment, before entering BWL treatment. Primary outcome is the amount of weight loss (%) at 6-month follow-up, compared with pre-treatment, derived from measured body weight. Secondary outcomes include improvement in executive functioning post-treatment and in weight loss-related behaviour, mental and physical health, and attendance to BWL treatment at 6-month and 12-month follow-up. Maintenance of weight loss at 12-month follow-up will be determined. Mixed model analyses based on intent-to-treat will be used to compare the CRT and control groups with respect to differences in weight change between pre-treatment and 6-month follow-up. Similar models will be used for analysing 12-month follow-up data and secondary outcomes. Further analyses will include additional covariates to identify predictors of treatment outcome. ETHICS AND DISSEMINATION: The study was approved by the Ethical Committee of the University of Leipzig (256-15-13072015, version ‘Final 1.0 from 28 May 2015). The study results will be disseminated through peer-reviewed publications. TRIAL REGISTRATION NUMBER: DRKS00009333; Pre-results. BMJ Publishing Group 2018-09-17 /pmc/articles/PMC6144388/ /pubmed/30224391 http://dx.doi.org/10.1136/bmjopen-2018-022616 Text en © Author(s) (or their employer(s)) 2018. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ. This is an open access article distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited, appropriate credit is given, any changes made indicated, and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/. |
spellingShingle | Nutrition and Metabolism Hilbert, Anja Blume, Marie Petroff, David Neuhaus, Petra Smith, Evelyn Hay, Phillipa J Hübner, Claudia Group cognitive remediation therapy for adults with obesity prior to behavioural weight loss treatment: study protocol for a randomised controlled superiority study (CRT study) |
title | Group cognitive remediation therapy for adults with obesity prior to behavioural weight loss treatment: study protocol for a randomised controlled superiority study (CRT study) |
title_full | Group cognitive remediation therapy for adults with obesity prior to behavioural weight loss treatment: study protocol for a randomised controlled superiority study (CRT study) |
title_fullStr | Group cognitive remediation therapy for adults with obesity prior to behavioural weight loss treatment: study protocol for a randomised controlled superiority study (CRT study) |
title_full_unstemmed | Group cognitive remediation therapy for adults with obesity prior to behavioural weight loss treatment: study protocol for a randomised controlled superiority study (CRT study) |
title_short | Group cognitive remediation therapy for adults with obesity prior to behavioural weight loss treatment: study protocol for a randomised controlled superiority study (CRT study) |
title_sort | group cognitive remediation therapy for adults with obesity prior to behavioural weight loss treatment: study protocol for a randomised controlled superiority study (crt study) |
topic | Nutrition and Metabolism |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6144388/ https://www.ncbi.nlm.nih.gov/pubmed/30224391 http://dx.doi.org/10.1136/bmjopen-2018-022616 |
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