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From Micro- to Nano-Multifunctional Theranostic Platform: Effective Ultrasound Imaging Is Not Just a Matter of Scale

Ultrasound Contrast Agents (UCAs) consisting of gas-filled-coated Microbubbles (MBs) with diameters between 1 and 10 µm have been used for a number of decades in diagnostic imaging. In recent years, submicron contrast agents have proven to be a viable alternative to MBs for ultrasound (US)-based app...

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Detalles Bibliográficos
Autores principales: Zullino, Sara, Argenziano, Monica, Stura, Ilaria, Guiot, Caterina, Cavalli, Roberta
Formato: Online Artículo Texto
Lenguaje:English
Publicado: SAGE Publications 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6144578/
https://www.ncbi.nlm.nih.gov/pubmed/30213222
http://dx.doi.org/10.1177/1536012118778216
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author Zullino, Sara
Argenziano, Monica
Stura, Ilaria
Guiot, Caterina
Cavalli, Roberta
author_facet Zullino, Sara
Argenziano, Monica
Stura, Ilaria
Guiot, Caterina
Cavalli, Roberta
author_sort Zullino, Sara
collection PubMed
description Ultrasound Contrast Agents (UCAs) consisting of gas-filled-coated Microbubbles (MBs) with diameters between 1 and 10 µm have been used for a number of decades in diagnostic imaging. In recent years, submicron contrast agents have proven to be a viable alternative to MBs for ultrasound (US)-based applications for their capability to extravasate and accumulate in the tumor tissue via the enhanced permeability and retention effect. After a short overview of the more recent approaches to ultrasound-mediated imaging and therapeutics at the nanoscale, phase-change contrast agents (PCCAs), which can be phase-transitioned into highly echogenic MBs by means of US, are here presented. The phenomenon of acoustic droplet vaporization (ADV) to produce bubbles is widely investigated for both imaging and therapeutic applications to develop promising theranostic platforms.
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spelling pubmed-61445782018-09-21 From Micro- to Nano-Multifunctional Theranostic Platform: Effective Ultrasound Imaging Is Not Just a Matter of Scale Zullino, Sara Argenziano, Monica Stura, Ilaria Guiot, Caterina Cavalli, Roberta Mol Imaging Theranostics Special Collection: Review Article Ultrasound Contrast Agents (UCAs) consisting of gas-filled-coated Microbubbles (MBs) with diameters between 1 and 10 µm have been used for a number of decades in diagnostic imaging. In recent years, submicron contrast agents have proven to be a viable alternative to MBs for ultrasound (US)-based applications for their capability to extravasate and accumulate in the tumor tissue via the enhanced permeability and retention effect. After a short overview of the more recent approaches to ultrasound-mediated imaging and therapeutics at the nanoscale, phase-change contrast agents (PCCAs), which can be phase-transitioned into highly echogenic MBs by means of US, are here presented. The phenomenon of acoustic droplet vaporization (ADV) to produce bubbles is widely investigated for both imaging and therapeutic applications to develop promising theranostic platforms. SAGE Publications 2018-09-13 /pmc/articles/PMC6144578/ /pubmed/30213222 http://dx.doi.org/10.1177/1536012118778216 Text en © The Author(s) 2018 http://creativecommons.org/licenses/by-nc/4.0/ This article is distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 License (http://www.creativecommons.org/licenses/by-nc/4.0/) which permits non-commercial use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access pages (https://us.sagepub.com/en-us/nam/open-access-at-sage).
spellingShingle Theranostics Special Collection: Review Article
Zullino, Sara
Argenziano, Monica
Stura, Ilaria
Guiot, Caterina
Cavalli, Roberta
From Micro- to Nano-Multifunctional Theranostic Platform: Effective Ultrasound Imaging Is Not Just a Matter of Scale
title From Micro- to Nano-Multifunctional Theranostic Platform: Effective Ultrasound Imaging Is Not Just a Matter of Scale
title_full From Micro- to Nano-Multifunctional Theranostic Platform: Effective Ultrasound Imaging Is Not Just a Matter of Scale
title_fullStr From Micro- to Nano-Multifunctional Theranostic Platform: Effective Ultrasound Imaging Is Not Just a Matter of Scale
title_full_unstemmed From Micro- to Nano-Multifunctional Theranostic Platform: Effective Ultrasound Imaging Is Not Just a Matter of Scale
title_short From Micro- to Nano-Multifunctional Theranostic Platform: Effective Ultrasound Imaging Is Not Just a Matter of Scale
title_sort from micro- to nano-multifunctional theranostic platform: effective ultrasound imaging is not just a matter of scale
topic Theranostics Special Collection: Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6144578/
https://www.ncbi.nlm.nih.gov/pubmed/30213222
http://dx.doi.org/10.1177/1536012118778216
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