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The role of interleukin-6-STAT3 signalling in glioblastoma
Glioblastoma is the most common type of malignant brain tumor among adults and is currently a non-curable disease due primarily to its highly invasive phenotype, and the lack of successful current therapies. Despite surgical resection and post-surgical treatment patients ultimately develop recurrenc...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
D.A. Spandidos
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6144698/ https://www.ncbi.nlm.nih.gov/pubmed/30250528 http://dx.doi.org/10.3892/ol.2018.9227 |
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author | West, Alice J. Tsui, Vanessa Stylli, Stanley S. Nguyen, Hong P.T. Morokoff, Andrew P. Kaye, Andrew H. Luwor, Rodney B. |
author_facet | West, Alice J. Tsui, Vanessa Stylli, Stanley S. Nguyen, Hong P.T. Morokoff, Andrew P. Kaye, Andrew H. Luwor, Rodney B. |
author_sort | West, Alice J. |
collection | PubMed |
description | Glioblastoma is the most common type of malignant brain tumor among adults and is currently a non-curable disease due primarily to its highly invasive phenotype, and the lack of successful current therapies. Despite surgical resection and post-surgical treatment patients ultimately develop recurrence of the tumour. Several signalling molecules have been implicated in the development, progression and aggressiveness of glioblastoma. The present study reviewed the role of interleukin (IL)-6, a cytokine known to be important in activating several pro-oncogenic signaling pathways in glioblastoma. The current study particularly focused on the contribution of IL-6 in recurrent glioblastoma, with particular focus on glioblastoma stem cells and resistance to therapy. |
format | Online Article Text |
id | pubmed-6144698 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2018 |
publisher | D.A. Spandidos |
record_format | MEDLINE/PubMed |
spelling | pubmed-61446982018-09-24 The role of interleukin-6-STAT3 signalling in glioblastoma West, Alice J. Tsui, Vanessa Stylli, Stanley S. Nguyen, Hong P.T. Morokoff, Andrew P. Kaye, Andrew H. Luwor, Rodney B. Oncol Lett Review Glioblastoma is the most common type of malignant brain tumor among adults and is currently a non-curable disease due primarily to its highly invasive phenotype, and the lack of successful current therapies. Despite surgical resection and post-surgical treatment patients ultimately develop recurrence of the tumour. Several signalling molecules have been implicated in the development, progression and aggressiveness of glioblastoma. The present study reviewed the role of interleukin (IL)-6, a cytokine known to be important in activating several pro-oncogenic signaling pathways in glioblastoma. The current study particularly focused on the contribution of IL-6 in recurrent glioblastoma, with particular focus on glioblastoma stem cells and resistance to therapy. D.A. Spandidos 2018-10 2018-07-27 /pmc/articles/PMC6144698/ /pubmed/30250528 http://dx.doi.org/10.3892/ol.2018.9227 Text en Copyright: © West et al. This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License (https://creativecommons.org/licenses/by-nc-nd/4.0/) , which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made. |
spellingShingle | Review West, Alice J. Tsui, Vanessa Stylli, Stanley S. Nguyen, Hong P.T. Morokoff, Andrew P. Kaye, Andrew H. Luwor, Rodney B. The role of interleukin-6-STAT3 signalling in glioblastoma |
title | The role of interleukin-6-STAT3 signalling in glioblastoma |
title_full | The role of interleukin-6-STAT3 signalling in glioblastoma |
title_fullStr | The role of interleukin-6-STAT3 signalling in glioblastoma |
title_full_unstemmed | The role of interleukin-6-STAT3 signalling in glioblastoma |
title_short | The role of interleukin-6-STAT3 signalling in glioblastoma |
title_sort | role of interleukin-6-stat3 signalling in glioblastoma |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6144698/ https://www.ncbi.nlm.nih.gov/pubmed/30250528 http://dx.doi.org/10.3892/ol.2018.9227 |
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