Decoding non-random mutational signatures at Cas9 targeted sites

The mutation patterns at Cas9 targeted sites contain unique information regarding the nuclease activity and repair mechanisms in mammalian cells. However, analytical framework for extracting such information are lacking. Here, we present a novel computational platform called Rational InDel Meta-Anal...

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Detalles Bibliográficos
Autores principales: Taheri-Ghahfarokhi, Amir, Taylor, Benjamin J M, Nitsch, Roberto, Lundin, Anders, Cavallo, Anna-Lina, Madeyski-Bengtson, Katja, Karlsson, Fredrik, Clausen, Maryam, Hicks, Ryan, Mayr, Lorenz M, Bohlooly-Y, Mohammad, Maresca, Marcello
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2018
Materias:
Molecular Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6144780/
https://www.ncbi.nlm.nih.gov/pubmed/30032200
http://dx.doi.org/10.1093/nar/gky653

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