The sequence features that define efficient and specific hAGO2-dependent miRNA silencing guides

MicroRNAs (miRNAs) are ribonucleic acids (RNAs) of ∼21 nucleotides that interfere with the translation of messenger RNAs (mRNAs) and play significant roles in development and diseases. In bilaterian animals, the specificity of miRNA targeting is determined by sequence complementarity involving the s...

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Detalles Bibliográficos
Autores principales: Yan, Yifei, Acevedo, Mariana, Mignacca, Lian, Desjardins, Philippe, Scott, Nicolas, Imane, Roqaya, Quenneville, Jordan, Robitaille, Julie, Feghaly, Albert, Gagnon, Etienne, Ferbeyre, Gerardo, Major, François
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2018
Materias:
Gene regulation, Chromatin and Epigenetics
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6144789/
https://www.ncbi.nlm.nih.gov/pubmed/30239883
http://dx.doi.org/10.1093/nar/gky546

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