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Combined deficiency of Senataxin and DNA-PKcs causes DNA damage accumulation and neurodegeneration in spinal muscular atrophy

Chronic low levels of survival motor neuron (SMN) protein cause spinal muscular atrophy (SMA). SMN is ubiquitously expressed, but the mechanisms underlying predominant neuron degeneration in SMA are poorly understood. We report that chronic low levels of SMN cause Senataxin (SETX)-deficiency, which...

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Detalles Bibliográficos
Autores principales:	Kannan, Annapoorna, Bhatia, Kanchan, Branzei, Dana, Gangwani, Laxman
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Oxford University Press 2018
Materias:	Genome Integrity, Repair and Replication
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6144794/ https://www.ncbi.nlm.nih.gov/pubmed/30010942 http://dx.doi.org/10.1093/nar/gky641

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