In vivo genome-wide binding interactions of mouse and human constitutive androstane receptors reveal novel gene targets

The constitutive androstane receptor (CAR; NR1I3) is a nuclear receptor orchestrating complex roles in cell and systems biology. Species differences in CAR’s effector pathways remain poorly understood, including its role in regulating liver tumor promotion. We developed transgenic mouse models to as...

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Detalles Bibliográficos
Autores principales: Niu, Ben, Coslo, Denise M, Bataille, Alain R, Albert, Istvan, Pugh, B Franklin, Omiecinski, Curtis J
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2018
Materias:
Genomics
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6144799/
https://www.ncbi.nlm.nih.gov/pubmed/30102401
http://dx.doi.org/10.1093/nar/gky692

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