Structural insights into Drosophila-C3PO complex assembly and ‘Dynamic Side Port’ model in substrate entry and release

In Drosophila and human, component 3 promoter of RISC (C3PO), a heteromeric complex, enhances RISC assembly and promotes RISC activity. Here, we report crystal structure of full-length Drosophila C3PO (E126Q), an inactive C3PO mutant displaying much weaker RNA binding ability, at 2.1 Å resolution. I...

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Detalles Bibliográficos
Autores principales: Mo, Xiaobing, Yang, Xia, Yuan, Yuren Adam
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2018
Materias:
RNA and RNA-protein complexes
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6144819/
https://www.ncbi.nlm.nih.gov/pubmed/29860349
http://dx.doi.org/10.1093/nar/gky465

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6144819/
https://www.ncbi.nlm.nih.gov/pubmed/29860349
http://dx.doi.org/10.1093/nar/gky465

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