Cargando…
Structural insights into Drosophila-C3PO complex assembly and ‘Dynamic Side Port’ model in substrate entry and release
In Drosophila and human, component 3 promoter of RISC (C3PO), a heteromeric complex, enhances RISC assembly and promotes RISC activity. Here, we report crystal structure of full-length Drosophila C3PO (E126Q), an inactive C3PO mutant displaying much weaker RNA binding ability, at 2.1 Å resolution. I...
| Autores principales: | , , |
|---|---|
| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Oxford University Press
2018
|
| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6144819/ https://www.ncbi.nlm.nih.gov/pubmed/29860349 http://dx.doi.org/10.1093/nar/gky465 |