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HIV-1 Vpr and p21 restrict LINE-1 mobility

Long interspersed element-1 (LINE-1, L1) composes ∼17% of the human genome. However, genetic interactions between L1 and human immunodeficiency virus type 1 (HIV-1) remain poorly understood. In this study, we found that HIV-1 suppresses L1 retrotransposition. Notably, HIV-1 Vpr strongly inhibited re...

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Detalles Bibliográficos
Autores principales:	Kawano, Koudai, Doucet, Aurélien J, Ueno, Mikinori, Kariya, Ryusho, An, Wenfeng, Marzetta, Flavia, Kuroki, Misao, Turelli, Priscilla, Sukegawa, Sayaka, Okada, Seiji, Strebel, Klaus, Trono, Didier, Ariumi, Yasuo
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Oxford University Press 2018
Materias:	Molecular Biology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6144823/ https://www.ncbi.nlm.nih.gov/pubmed/30085096 http://dx.doi.org/10.1093/nar/gky688

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