Phase II evaluation of anti-MAdCAM antibody PF-00547659 in the treatment of Crohn’s disease: report of the OPERA study

OBJECTIVE: This phase II, randomised, double-blind, placebo-controlled clinical trial was designed to evaluate the efficacy and safety of PF-00547659, a fully human monoclonal antibody that binds to human mucosal addressin cell adhesion molecule (MAdCAM) to selectively reduce lymphocyte homing to th...

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Detalles Bibliográficos
Autores principales: Sandborn, William J, Lee, Scott D, Tarabar, Dino, Louis, Edouard, Klopocka, Maria, Klaus, Jochen, Reinisch, Walter, Hébuterne, Xavier, Park, Dong-Il, Schreiber, Stefan, Nayak, Satyaprakash, Ahmad, Alaa, Banerjee, Anindita, Brown, Lisa S, Cataldi, Fabio, Gorelick, Kenneth J, Cheng, John B, Hassan-Zahraee, Mina, Clare, Robert, D’Haens, Geert R
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BMJ Publishing Group 2018
Materias:
Inflammatory Bowel Disease
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6145284/
https://www.ncbi.nlm.nih.gov/pubmed/28982740
http://dx.doi.org/10.1136/gutjnl-2016-313457

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6145284/
https://www.ncbi.nlm.nih.gov/pubmed/28982740
http://dx.doi.org/10.1136/gutjnl-2016-313457

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