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Lycium europaeum Extract: A New Potential Antioxidant Source against Cisplatin-Induced Liver and Kidney Injuries in Mice

This study was designed to assess the protective effects of Lycium europaeum methanol extract (LEM) on liver and kidney injuries induced by cisplatin. The phytochemical composition, the antioxidant activity, and hepatorenal injury biomarkers were investigated. Results revealed that LEM exhibited a s...

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Autores principales: Rjeibi, Ilhem, Feriani, Anouar, Ben Saad, Anouar, Sdayria, Jazia, Saidi, Issam, Ncib, Sana, Souid, Sami, Allagui, Mohamed Salah, Hfaiedh, Najla
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6145318/
https://www.ncbi.nlm.nih.gov/pubmed/30254713
http://dx.doi.org/10.1155/2018/1630751
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author Rjeibi, Ilhem
Feriani, Anouar
Ben Saad, Anouar
Sdayria, Jazia
Saidi, Issam
Ncib, Sana
Souid, Sami
Allagui, Mohamed Salah
Hfaiedh, Najla
author_facet Rjeibi, Ilhem
Feriani, Anouar
Ben Saad, Anouar
Sdayria, Jazia
Saidi, Issam
Ncib, Sana
Souid, Sami
Allagui, Mohamed Salah
Hfaiedh, Najla
author_sort Rjeibi, Ilhem
collection PubMed
description This study was designed to assess the protective effects of Lycium europaeum methanol extract (LEM) on liver and kidney injuries induced by cisplatin. The phytochemical composition, the antioxidant activity, and hepatorenal injury biomarkers were investigated. Results revealed that LEM exhibited a significant antioxidant activity in vitro on DPPH radical and H(2)O(2) scavenging assays. In the animal studies, treatment with LEM significantly reduced the effects of cisplatin intoxication on serum liver biomarkers and serum renal biomarkers. Meanwhile, LEM diminishes significantly the effect of cisplatin on the level of lipid peroxidation in liver and kidney tissues. The activities of the antioxidant enzymes (reduced glutathione, glutathione peroxidase, superoxide dismutase, and catalase) were increased in groups pretreated with LEM and quercetin. Additionally, the normal histological structures of the liver and kidney were restored after treatment with LEM. This work clearly demonstrated that L. europaeum may be useful as a drug with hepato-nephroprotective potentials.
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spelling pubmed-61453182018-09-25 Lycium europaeum Extract: A New Potential Antioxidant Source against Cisplatin-Induced Liver and Kidney Injuries in Mice Rjeibi, Ilhem Feriani, Anouar Ben Saad, Anouar Sdayria, Jazia Saidi, Issam Ncib, Sana Souid, Sami Allagui, Mohamed Salah Hfaiedh, Najla Oxid Med Cell Longev Research Article This study was designed to assess the protective effects of Lycium europaeum methanol extract (LEM) on liver and kidney injuries induced by cisplatin. The phytochemical composition, the antioxidant activity, and hepatorenal injury biomarkers were investigated. Results revealed that LEM exhibited a significant antioxidant activity in vitro on DPPH radical and H(2)O(2) scavenging assays. In the animal studies, treatment with LEM significantly reduced the effects of cisplatin intoxication on serum liver biomarkers and serum renal biomarkers. Meanwhile, LEM diminishes significantly the effect of cisplatin on the level of lipid peroxidation in liver and kidney tissues. The activities of the antioxidant enzymes (reduced glutathione, glutathione peroxidase, superoxide dismutase, and catalase) were increased in groups pretreated with LEM and quercetin. Additionally, the normal histological structures of the liver and kidney were restored after treatment with LEM. This work clearly demonstrated that L. europaeum may be useful as a drug with hepato-nephroprotective potentials. Hindawi 2018-09-05 /pmc/articles/PMC6145318/ /pubmed/30254713 http://dx.doi.org/10.1155/2018/1630751 Text en Copyright © 2018 Ilhem Rjeibi et al. http://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Rjeibi, Ilhem
Feriani, Anouar
Ben Saad, Anouar
Sdayria, Jazia
Saidi, Issam
Ncib, Sana
Souid, Sami
Allagui, Mohamed Salah
Hfaiedh, Najla
Lycium europaeum Extract: A New Potential Antioxidant Source against Cisplatin-Induced Liver and Kidney Injuries in Mice
title Lycium europaeum Extract: A New Potential Antioxidant Source against Cisplatin-Induced Liver and Kidney Injuries in Mice
title_full Lycium europaeum Extract: A New Potential Antioxidant Source against Cisplatin-Induced Liver and Kidney Injuries in Mice
title_fullStr Lycium europaeum Extract: A New Potential Antioxidant Source against Cisplatin-Induced Liver and Kidney Injuries in Mice
title_full_unstemmed Lycium europaeum Extract: A New Potential Antioxidant Source against Cisplatin-Induced Liver and Kidney Injuries in Mice
title_short Lycium europaeum Extract: A New Potential Antioxidant Source against Cisplatin-Induced Liver and Kidney Injuries in Mice
title_sort lycium europaeum extract: a new potential antioxidant source against cisplatin-induced liver and kidney injuries in mice
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6145318/
https://www.ncbi.nlm.nih.gov/pubmed/30254713
http://dx.doi.org/10.1155/2018/1630751
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