Netrin-1 attenuates brain injury after middle cerebral artery occlusion via downregulation of astrocyte activation in mice

BACKGROUND: Netrin-1 functions largely via combined receptors and downstream effectors. Evidence has shown that astrocytes express netrin-1 receptors, including DCC and UNC5H2. However, whether netrin-1 influences the function of astrocytes was previously unknown. METHODS: Lipopolysaccharide was use...

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Detalles Bibliográficos
Autores principales: He, Xiaosong, Liu, Yanqun, Lin, Xiaohong, Yuan, Falei, Long, Dahong, Zhang, Zhijun, Wang, Yongting, Xuan, Aiguo, Yang, Guo-Yuan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2018
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6145326/
https://www.ncbi.nlm.nih.gov/pubmed/30227858
http://dx.doi.org/10.1186/s12974-018-1291-5

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