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Leakage of an Invagination Pancreaticojejunostomy May Have an Influence on Mortality
Purpose: No consensus exists regarding the most effective form of pancreaticojejunostomy (PJ) following pancreaticoduodenectomy (PD). Methods: Data were gathered through the American College of Surgeons-National Surgical Quality Improvement Program, Pancreatectomy Demonstration Project. A total of 1...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Mary Ann Liebert, Inc.
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6145537/ https://www.ncbi.nlm.nih.gov/pubmed/30631858 http://dx.doi.org/10.1089/pancan.2018.0008 |
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author | Lavu, Harish McCall, Neal Keith, Scott W. Kilbane, Elizabeth M. Parmar, Abhishek D. Hall, Bruce L. Pitt, Henry A. |
author_facet | Lavu, Harish McCall, Neal Keith, Scott W. Kilbane, Elizabeth M. Parmar, Abhishek D. Hall, Bruce L. Pitt, Henry A. |
author_sort | Lavu, Harish |
collection | PubMed |
description | Purpose: No consensus exists regarding the most effective form of pancreaticojejunostomy (PJ) following pancreaticoduodenectomy (PD). Methods: Data were gathered through the American College of Surgeons-National Surgical Quality Improvement Program, Pancreatectomy Demonstration Project. A total of 1781 patients underwent a PD at 43 institutions. After appropriate exclusions, 890 patients were analyzed. Patients were divided into duct-to-mucosa (n = 734, 82%) and invagination (n = 156, 18%) groups and were compared by unadjusted analysis. Type of PJ was included in eight separate morbidity and mortality multivariable analyses. Results: Invagination patients had higher serum albumin (p < 0.01) and lower body mass index (p < 0.01), were less likely to have a preoperative biliary stent (p < 0.01), and were more likely to have a soft gland (p < 0.01). PJ anastomosis type was not associated with morbidity but was associated with mortality (duct-to-mucosa vs. invagination, odds ratio = 0.22, p < 0.01). Among patients who developed a clinically relevant pancreatic fistula, none of the 119 duct-to-mucosa, compared with 5 of 21 invagination, patients died (p < 0.01). Conclusion: Patients who undergo a PJ by duct-to-mucosa or invagination differ with respect to preoperative and intraoperative variables. When an invagination PJ leaks, there may be a greater influence on mortality than when a duct-to-mucosa PJ leaks. |
format | Online Article Text |
id | pubmed-6145537 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2018 |
publisher | Mary Ann Liebert, Inc. |
record_format | MEDLINE/PubMed |
spelling | pubmed-61455372019-01-10 Leakage of an Invagination Pancreaticojejunostomy May Have an Influence on Mortality Lavu, Harish McCall, Neal Keith, Scott W. Kilbane, Elizabeth M. Parmar, Abhishek D. Hall, Bruce L. Pitt, Henry A. J Pancreat Cancer Original Article Purpose: No consensus exists regarding the most effective form of pancreaticojejunostomy (PJ) following pancreaticoduodenectomy (PD). Methods: Data were gathered through the American College of Surgeons-National Surgical Quality Improvement Program, Pancreatectomy Demonstration Project. A total of 1781 patients underwent a PD at 43 institutions. After appropriate exclusions, 890 patients were analyzed. Patients were divided into duct-to-mucosa (n = 734, 82%) and invagination (n = 156, 18%) groups and were compared by unadjusted analysis. Type of PJ was included in eight separate morbidity and mortality multivariable analyses. Results: Invagination patients had higher serum albumin (p < 0.01) and lower body mass index (p < 0.01), were less likely to have a preoperative biliary stent (p < 0.01), and were more likely to have a soft gland (p < 0.01). PJ anastomosis type was not associated with morbidity but was associated with mortality (duct-to-mucosa vs. invagination, odds ratio = 0.22, p < 0.01). Among patients who developed a clinically relevant pancreatic fistula, none of the 119 duct-to-mucosa, compared with 5 of 21 invagination, patients died (p < 0.01). Conclusion: Patients who undergo a PJ by duct-to-mucosa or invagination differ with respect to preoperative and intraoperative variables. When an invagination PJ leaks, there may be a greater influence on mortality than when a duct-to-mucosa PJ leaks. Mary Ann Liebert, Inc. 2018-08-01 /pmc/articles/PMC6145537/ /pubmed/30631858 http://dx.doi.org/10.1089/pancan.2018.0008 Text en © Harish Lavu et al. 2018; Published by Mary Ann Liebert, Inc. This Open Access article is distributed under the terms of the Creative Commons License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Original Article Lavu, Harish McCall, Neal Keith, Scott W. Kilbane, Elizabeth M. Parmar, Abhishek D. Hall, Bruce L. Pitt, Henry A. Leakage of an Invagination Pancreaticojejunostomy May Have an Influence on Mortality |
title | Leakage of an Invagination Pancreaticojejunostomy May Have an Influence on Mortality |
title_full | Leakage of an Invagination Pancreaticojejunostomy May Have an Influence on Mortality |
title_fullStr | Leakage of an Invagination Pancreaticojejunostomy May Have an Influence on Mortality |
title_full_unstemmed | Leakage of an Invagination Pancreaticojejunostomy May Have an Influence on Mortality |
title_short | Leakage of an Invagination Pancreaticojejunostomy May Have an Influence on Mortality |
title_sort | leakage of an invagination pancreaticojejunostomy may have an influence on mortality |
topic | Original Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6145537/ https://www.ncbi.nlm.nih.gov/pubmed/30631858 http://dx.doi.org/10.1089/pancan.2018.0008 |
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