Cargando…

Tubulin's response to external electric fields by molecular dynamics simulations

Tubulin heterodimers are the building blocks of microtubules and disruption of their dynamics is exploited in the treatment of cancer. Electric fields at certain frequencies and magnitudes are believed to do the same. Here, the tubulin dimer’s response to external electric fields was determined by a...

Descripción completa

Detalles Bibliográficos
Autores principales:	Timmons, Joshua J., Preto, Jordane, Tuszynski, Jack A., Wong, Eric T.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2018
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6145594/ https://www.ncbi.nlm.nih.gov/pubmed/30231050 http://dx.doi.org/10.1371/journal.pone.0202141

Ejemplares similares

Tubulin response to intense nanosecond-scale electric field in molecular dynamics simulation
por: Marracino, Paolo, et al.
Publicado: (2019)

Modeling the Colchicum autumnale Tubulin and a Comparison of Its Interaction with Colchicine to Human Tubulin
por: Spasevska, Ivana, et al.
Publicado: (2017)

Behavior of α, β tubulin in DMSO-containing electrolytes
por: Kalra, Aarat P., et al.
Publicado: (2019)

Synthesis and Biological Evaluation of Novel Triple-Modified Colchicine Derivatives as Potent Tubulin-Targeting Anticancer Agents
por: Majcher, Urszula, et al.
Publicado: (2018)

Anesthetic Alterations of Collective Terahertz Oscillations in Tubulin Correlate with Clinical Potency: Implications for Anesthetic Action and Post-Operative Cognitive Dysfunction
por: Craddock, Travis J. A., et al.
Publicado: (2017)

Response to Alternating Electric Fields of Tubulin Dimers and Microtubule Ensembles in Electrolytic Solutions
por: Santelices, Iara B., et al.
Publicado: (2017)

An Overview of Sub-Cellular Mechanisms Involved in the Action of TTFields
por: Tuszynski, Jack A., et al.
Publicado: (2016)

A Review of the Recent Developments of Molecular Hybrids Targeting Tubulin Polymerization
por: Ebenezer, Oluwakemi, et al.
Publicado: (2022)

Tubulin: Structure, Functions and Roles in Disease
por: Binarová, Pavla, et al.
Publicado: (2019)

Investigation of the Electrical Properties of Microtubule Ensembles under Cell-Like Conditions
por: Kalra, Aarat P., et al.
Publicado: (2020)

Molecular docking and dynamic simulations of benzimidazoles with beta-tubulins
por: Rao, Chennu Maruthi Malya Prasada, et al.
Publicado: (2021)

The transport of a charged peptide through carbon nanotubes under an external electric field: a molecular dynamics simulation
por: Li, Wen, et al.
Publicado: (2021)

Tubulin Polarizability in Aqueous Suspensions
por: Guzman-Sepulveda, Jose Rafael, et al.
Publicado: (2019)

A Deep Dive into VDAC1 Conformational Diversity Using All-Atom Simulations Provides New Insights into the Structural Origin of the Closed States
por: Preto, Jordane, et al.
Publicado: (2022)

Enhancing the Oxidation of Toluene with External Electric Fields: a Reactive Molecular Dynamics Study
por: Tan, Shen, et al.
Publicado: (2017)

Molecular dynamics simulation dataset of a microtubule ring in electric field
por: Průša, Jiří, et al.
Publicado: (2021)

The penetration of a charged peptide across a membrane under an external electric field: a coarse-grained molecular dynamics simulation
por: Wang, Bin, et al.
Publicado: (2018)

Alteration of lipid bilayer mechanics by volatile anesthetics: Insights from μs-long molecular dynamics simulations
por: Zizzi, Eric A., et al.
Publicado: (2022)

Molecular Docking and Dynamics Simulation of Protein β-Tubulin and Antifungal Cyclic Lipopeptides
por: Cob-Calan, Nubia Noemi, et al.
Publicado: (2019)

Atomistic molecular dynamics simulations of tubulin heterodimers explain the motion of a microtubule
por: Nasedkin, Alexandr, et al.
Publicado: (2021)

Atomic Resolution Homology Models and Molecular Dynamics Simulations of Plasmodium falciparum Tubulins
por: Hema, Kanipakam, et al.
Publicado: (2021)

Ab Initio Molecular Dynamics Study of Methanol-Water Mixtures under External Electric Fields
por: Cassone, Giuseppe, et al.
Publicado: (2020)

Soybean Hydrophobic Protein Response to External Electric Field: A Molecular Modeling Approach
por: Singh, Ashutosh, et al.
Publicado: (2013)

The Roles of β-Tubulin Mutations and Isotype Expression in Acquired Drug Resistance
por: Huzil, J. Torin, et al.
Publicado: (2007)

Molecular dynamics simulation of the nanosecond pulsed electric field effect on kinesin nanomotor
por: Průša, Jiří, et al.
Publicado: (2019)

Effect of Electric Field on α-Synuclein Fibrils: Revealed by Molecular Dynamics Simulations
por: Razzokov, Jamoliddin, et al.
Publicado: (2023)

A Molecular Docking Study Reveals That Short Peptides Induce Conformational Changes in the Structure of Human Tubulin Isotypes αβI, αβII, αβIII and αβIV
por: Ebenezer, Oluwakemi, et al.
Publicado: (2023)

Determination of the optimal tubulin isotype target as a method for the development of individualized cancer chemotherapy
por: Ravanbakhsh, Siamak, et al.
Publicado: (2013)

Comparative Analysis, Structural Insights, and Substrate/Drug Interaction of CYP128A1 in Mycobacterium tuberculosis
por: Ngcobo, Nokwanda Samantha, et al.
Publicado: (2020)

Tyrosine Kinase Inhibitors Reduce Glucose Uptake by Binding to an Exofacial Site on hGLUT‐1: Influence on (18)F‐FDG PET Uptake
por: Damaraju, Vijaya L., et al.
Publicado: (2021)

Response of the electric field gradient in ion implanted BaTiO$_{3}$ to an external electric field
por: Dietrich, M, et al.
Publicado: (2000)

Fluctuation Relations for Dissipative Systems in Constant External Magnetic Field: Theory and Molecular Dynamics Simulations
por: Coretti, Alessandro, et al.
Publicado: (2021)

The intrinsically disordered N-terminus of the voltage-dependent anion channel
por: Preto, Jordane, et al.
Publicado: (2021)

Thermal hysteresis in microtubule assembly/disassembly dynamics: The aging-induced degradation of tubulin dimers
por: Wu, R., et al.
Publicado: (2022)

Electronic processes in molecular dynamics simulations of nanoscale metal tips under electric fields
por: Parviainen, S, et al.
Publicado: (2011)

Effects of an Electric Field on the Conformational Transition of the Protein: A Molecular Dynamics Simulation Study
por: Jiang, Zhouting, et al.
Publicado: (2019)

Molecular Dynamics Simulation for the Demulsification of O/W Emulsion under Pulsed Electric Field
por: Liu, Shasha, et al.
Publicado: (2022)

In silico Investigations of the Mode of Action of Novel Colchicine Derivatives Targeting β-Tubulin Isotypes: A Search for a Selective and Specific β-III Tubulin Ligand
por: Pallante, Lorenzo, et al.
Publicado: (2020)

Editorial: The isotypes of α, β and γ tubulin: From evolutionary origins to roles in metazoan development and ligand binding differences
por: Moore, Jeffrey, et al.
Publicado: (2023)

Understanding the Basis of Drug Resistance of the Mutants of αβ-Tubulin Dimer via Molecular Dynamics Simulations
por: Natarajan, Kathiresan, et al.
Publicado: (2012)

Cannot write session to /tmp/vufind_sessions/sess_iqgva23tsf9r583t5ulrffmq6u