The Jumonji-domain histone demethylase inhibitor JIB-04 deregulates oncogenic programs and increases DNA damage in Ewing Sarcoma, resulting in impaired cell proliferation and survival, and reduced tumor growth

Ewing Sarcoma is an aggressive malignant neoplasm affecting children and young adults. Ewing Sarcoma is driven by transcription factor fusion oncoproteins, most commonly EWS/Fli1. While some patients can be cured with high-dose, multi-agent, chemotherapy, those that cannot currently have few options...

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Detalles Bibliográficos
Autores principales: Parrish, Janet K., McCann, Tyler S., Sechler, Marybeth, Sobral, Lays M., Ren, Wenhua, Jones, Kenneth L., Tan, Aik Choon, Jedlicka, Paul
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2018
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6145692/
https://www.ncbi.nlm.nih.gov/pubmed/30237855
http://dx.doi.org/10.18632/oncotarget.26011

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