Comparison of oxidative stress under different propofol administration protocols in Thoroughbred racehorses by bOS and bAP assessment

It is desirable to reduce surgery-induced oxidative stress (OS) because it can cause immune suppression and delayed wound healing. Propofol is known to have antioxidant potential and to reduce OS in humans, but there have been no studies of this issue in horses. This study was conducted to evaluate...

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Detalles Bibliográficos
Autores principales: KAMBAYASHI, Yoshinori, TSUZUKI, Nao, TOKUSHIGE, Hirotaka, KUSANO, Kanichi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Japanese Society of Equine Science 2018
Materias:
Note
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6145865/
https://www.ncbi.nlm.nih.gov/pubmed/30250395
http://dx.doi.org/10.1294/jes.29.75
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author KAMBAYASHI, Yoshinori
TSUZUKI, Nao
TOKUSHIGE, Hirotaka
KUSANO, Kanichi
author_facet KAMBAYASHI, Yoshinori
TSUZUKI, Nao
TOKUSHIGE, Hirotaka
KUSANO, Kanichi
author_sort KAMBAYASHI, Yoshinori
collection PubMed
description It is desirable to reduce surgery-induced oxidative stress (OS) because it can cause immune suppression and delayed wound healing. Propofol is known to have antioxidant potential and to reduce OS in humans, but there have been no studies of this issue in horses. This study was conducted to evaluate OS under three different propofol administration protocols in Thoroughbred racehorses undergoing arthroscopic surgery with sevoflurane anesthesia. Blood oxidative stress (bOS) and blood antioxidant power (bAP) were used as OS biomarkers. Both bOS and bAP significantly decreased after surgery in all groups, but no differences in these reductions were found among them. Different propofol administration protocols with sevoflurane anesthesia did not cause a difference in OS in Thoroughbred racehorses that underwent arthroscopic surgery.
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spelling pubmed-61458652018-09-24 Comparison of oxidative stress under different propofol administration protocols in Thoroughbred racehorses by bOS and bAP assessment KAMBAYASHI, Yoshinori TSUZUKI, Nao TOKUSHIGE, Hirotaka KUSANO, Kanichi J Equine Sci Note It is desirable to reduce surgery-induced oxidative stress (OS) because it can cause immune suppression and delayed wound healing. Propofol is known to have antioxidant potential and to reduce OS in humans, but there have been no studies of this issue in horses. This study was conducted to evaluate OS under three different propofol administration protocols in Thoroughbred racehorses undergoing arthroscopic surgery with sevoflurane anesthesia. Blood oxidative stress (bOS) and blood antioxidant power (bAP) were used as OS biomarkers. Both bOS and bAP significantly decreased after surgery in all groups, but no differences in these reductions were found among them. Different propofol administration protocols with sevoflurane anesthesia did not cause a difference in OS in Thoroughbred racehorses that underwent arthroscopic surgery. The Japanese Society of Equine Science 2018-09-19 2018-09 /pmc/articles/PMC6145865/ /pubmed/30250395 http://dx.doi.org/10.1294/jes.29.75 Text en ©2018 The Japanese Society of Equine Science This is an open-access article distributed under the terms of the Creative Commons Attribution Non-Commercial No Derivatives (by-nc-nd) License. (CC-BY-NC-ND 4.0: https://creativecommons.org/licenses/by-nc-nd/4.0/)
spellingShingle Note
KAMBAYASHI, Yoshinori
TSUZUKI, Nao
TOKUSHIGE, Hirotaka
KUSANO, Kanichi
Comparison of oxidative stress under different propofol administration protocols in Thoroughbred racehorses by bOS and bAP assessment
title Comparison of oxidative stress under different propofol administration protocols in Thoroughbred racehorses by bOS and bAP assessment
title_full Comparison of oxidative stress under different propofol administration protocols in Thoroughbred racehorses by bOS and bAP assessment
title_fullStr Comparison of oxidative stress under different propofol administration protocols in Thoroughbred racehorses by bOS and bAP assessment
title_full_unstemmed Comparison of oxidative stress under different propofol administration protocols in Thoroughbred racehorses by bOS and bAP assessment
title_short Comparison of oxidative stress under different propofol administration protocols in Thoroughbred racehorses by bOS and bAP assessment
title_sort comparison of oxidative stress under different propofol administration protocols in thoroughbred racehorses by bos and bap assessment
topic Note
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6145865/
https://www.ncbi.nlm.nih.gov/pubmed/30250395
http://dx.doi.org/10.1294/jes.29.75
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