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An alternative pathway of enteric PEDV dissemination from nasal cavity to intestinal mucosa in swine
Porcine epidemic diarrhea virus (PEDV) has catastrophic impacts on the global pig industry. Although the fecal–oral route is generally accepted, an increased number of reports indicate that airborne transmission may contribute to PEDV outbreak. Here, we show that PEDV could cause typical diarrhea in...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6145876/ https://www.ncbi.nlm.nih.gov/pubmed/30232333 http://dx.doi.org/10.1038/s41467-018-06056-w |
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author | Li, Yuchen Wu, Qingxin Huang, Lulu Yuan, Chen Wang, Jialu Yang, Qian |
author_facet | Li, Yuchen Wu, Qingxin Huang, Lulu Yuan, Chen Wang, Jialu Yang, Qian |
author_sort | Li, Yuchen |
collection | PubMed |
description | Porcine epidemic diarrhea virus (PEDV) has catastrophic impacts on the global pig industry. Although the fecal–oral route is generally accepted, an increased number of reports indicate that airborne transmission may contribute to PEDV outbreak. Here, we show that PEDV could cause typical diarrhea in piglets through a nasal spray. Firstly, PEDV can develop a transient nasal epithelium infection. Subsequently, PEDV-carrying dendritic cells (DCs) allow the virus to be transferred to CD3(+) T cells via the virological synapse. Finally, virus-loaded CD3(+) T cells reach the intestine through the blood circulation, leading to intestinal infection via cell-to-cell contact. Our study provides evidence for airborne transmission of a gastrointestinal infected coronavirus and illustrates the mechanism of its transport from the entry site to the pathogenic site. |
format | Online Article Text |
id | pubmed-6145876 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2018 |
publisher | Nature Publishing Group UK |
record_format | MEDLINE/PubMed |
spelling | pubmed-61458762018-09-24 An alternative pathway of enteric PEDV dissemination from nasal cavity to intestinal mucosa in swine Li, Yuchen Wu, Qingxin Huang, Lulu Yuan, Chen Wang, Jialu Yang, Qian Nat Commun Article Porcine epidemic diarrhea virus (PEDV) has catastrophic impacts on the global pig industry. Although the fecal–oral route is generally accepted, an increased number of reports indicate that airborne transmission may contribute to PEDV outbreak. Here, we show that PEDV could cause typical diarrhea in piglets through a nasal spray. Firstly, PEDV can develop a transient nasal epithelium infection. Subsequently, PEDV-carrying dendritic cells (DCs) allow the virus to be transferred to CD3(+) T cells via the virological synapse. Finally, virus-loaded CD3(+) T cells reach the intestine through the blood circulation, leading to intestinal infection via cell-to-cell contact. Our study provides evidence for airborne transmission of a gastrointestinal infected coronavirus and illustrates the mechanism of its transport from the entry site to the pathogenic site. Nature Publishing Group UK 2018-09-19 /pmc/articles/PMC6145876/ /pubmed/30232333 http://dx.doi.org/10.1038/s41467-018-06056-w Text en © The Author(s) 2018 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/. |
spellingShingle | Article Li, Yuchen Wu, Qingxin Huang, Lulu Yuan, Chen Wang, Jialu Yang, Qian An alternative pathway of enteric PEDV dissemination from nasal cavity to intestinal mucosa in swine |
title | An alternative pathway of enteric PEDV dissemination from nasal cavity to intestinal mucosa in swine |
title_full | An alternative pathway of enteric PEDV dissemination from nasal cavity to intestinal mucosa in swine |
title_fullStr | An alternative pathway of enteric PEDV dissemination from nasal cavity to intestinal mucosa in swine |
title_full_unstemmed | An alternative pathway of enteric PEDV dissemination from nasal cavity to intestinal mucosa in swine |
title_short | An alternative pathway of enteric PEDV dissemination from nasal cavity to intestinal mucosa in swine |
title_sort | alternative pathway of enteric pedv dissemination from nasal cavity to intestinal mucosa in swine |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6145876/ https://www.ncbi.nlm.nih.gov/pubmed/30232333 http://dx.doi.org/10.1038/s41467-018-06056-w |
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