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Genetic variant in IL-32 is associated with the ex vivo cytokine production of anti-TNF treated PBMCs from rheumatoid arthritis patients

About 60% of RA patients don’t achieve good response with biological disease-modifying anti-rheumatic drugs bDMARD treatment (including TNF inhibitors, TNFi’s). Previously, a link between TNFα and interleukin (IL)-32 was reported in RA. However, the exact mechanism linking IL-32 to response to treat...

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Detalles Bibliográficos
Autores principales:	Damen, Michelle S. M. A., Schraa, Kiki, Tweehuysen, Lieke, den Broeder, Alfons A., Netea, Mihai G., Popa, Calin D., Joosten, Leo A. B.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2018
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6145899/ https://www.ncbi.nlm.nih.gov/pubmed/30232372 http://dx.doi.org/10.1038/s41598-018-32485-0

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