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Rv2346c enhances mycobacterial survival within macrophages by inhibiting TNF-α and IL-6 production via the p38/miRNA/NF-κB pathway

The intracellular survival of Mycobacterium tuberculosis (Mtb) has a central role in the pathogenesis of tuberculosis. Mtb Rv2346c is a member of 6-kDa early secreted antigenic target family of proteins, which are known to inhibit the host immune responses to promote bacillary persistence in macroph...

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Detalles Bibliográficos
Autores principales:	Yao, Jing, Du, Xingran, Chen, Sixia, Shao, Yan, Deng, Kaili, Jiang, Mingzi, Liu, Jingning, Shen, Ziyan, Chen, Xiaolin, Feng, Ganzhu
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2018
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6145905/ https://www.ncbi.nlm.nih.gov/pubmed/30232332 http://dx.doi.org/10.1038/s41426-018-0162-6

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