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Calpain-10 and Adiponectin Gene Polymorphisms in Korean Type 2 Diabetes Patients
BACKGROUND: Genetic variations in calpain-10 and adiponectin gene are known to influence insulin secretion and resistance in type 2 diabetes mellitus. Recently, several single nucleotide polymorphisms (SNPs) in calpain-10 and adiponectin gene have been reported to be associated with type 2 diabetes...
Autores principales: | , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Korean Endocrine Society
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6145956/ https://www.ncbi.nlm.nih.gov/pubmed/30229575 http://dx.doi.org/10.3803/EnM.2018.33.3.364 |
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author | Nam, Ji Sun Han, Jung Woo Lee, Sang Bae You, Ji Hong Kim, Min Jin Kang, Shinae Park, Jong Suk Ahn, Chul Woo |
author_facet | Nam, Ji Sun Han, Jung Woo Lee, Sang Bae You, Ji Hong Kim, Min Jin Kang, Shinae Park, Jong Suk Ahn, Chul Woo |
author_sort | Nam, Ji Sun |
collection | PubMed |
description | BACKGROUND: Genetic variations in calpain-10 and adiponectin gene are known to influence insulin secretion and resistance in type 2 diabetes mellitus. Recently, several single nucleotide polymorphisms (SNPs) in calpain-10 and adiponectin gene have been reported to be associated with type 2 diabetes and various metabolic derangements. We investigated the associations between specific calpain-10 and adiponectin gene polymorphisms and Korean type 2 diabetes patients. METHODS: Overall, 249 type 2 diabetes patients and 131 non-diabetic control subjects were enrolled in this study. All the subjects were genotyped for SNP-43 and -63 of calpain-10 gene and G276T and T45G frequencies of the adiponectin gene. The clinical characteristics and measure of glucose metabolism were compared within these genotypes. RESULTS: Among calpain-10 polymorphisms, SNP-63 T/T were more frequent in diabetes patients, and single SNP-63 increases the susceptibility to type 2 diabetes. However, SNP-43 in calpain-10 and T45G and intron G276T in adiponectin gene were not significantly associated with diabetes, insulin resistance, nor insulin secretion. CONCLUSION: Variations in calpain-10, SNP-63 seems to increase the susceptibility to type 2 diabetes in Koreans while SNP-43 and adiponectin SNP-45, -276 are not associated with impaired glucose metabolism. |
format | Online Article Text |
id | pubmed-6145956 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2018 |
publisher | Korean Endocrine Society |
record_format | MEDLINE/PubMed |
spelling | pubmed-61459562018-09-25 Calpain-10 and Adiponectin Gene Polymorphisms in Korean Type 2 Diabetes Patients Nam, Ji Sun Han, Jung Woo Lee, Sang Bae You, Ji Hong Kim, Min Jin Kang, Shinae Park, Jong Suk Ahn, Chul Woo Endocrinol Metab (Seoul) Original Article BACKGROUND: Genetic variations in calpain-10 and adiponectin gene are known to influence insulin secretion and resistance in type 2 diabetes mellitus. Recently, several single nucleotide polymorphisms (SNPs) in calpain-10 and adiponectin gene have been reported to be associated with type 2 diabetes and various metabolic derangements. We investigated the associations between specific calpain-10 and adiponectin gene polymorphisms and Korean type 2 diabetes patients. METHODS: Overall, 249 type 2 diabetes patients and 131 non-diabetic control subjects were enrolled in this study. All the subjects were genotyped for SNP-43 and -63 of calpain-10 gene and G276T and T45G frequencies of the adiponectin gene. The clinical characteristics and measure of glucose metabolism were compared within these genotypes. RESULTS: Among calpain-10 polymorphisms, SNP-63 T/T were more frequent in diabetes patients, and single SNP-63 increases the susceptibility to type 2 diabetes. However, SNP-43 in calpain-10 and T45G and intron G276T in adiponectin gene were not significantly associated with diabetes, insulin resistance, nor insulin secretion. CONCLUSION: Variations in calpain-10, SNP-63 seems to increase the susceptibility to type 2 diabetes in Koreans while SNP-43 and adiponectin SNP-45, -276 are not associated with impaired glucose metabolism. Korean Endocrine Society 2018-09 2018-09-18 /pmc/articles/PMC6145956/ /pubmed/30229575 http://dx.doi.org/10.3803/EnM.2018.33.3.364 Text en Copyright © 2018 Korean Endocrine Society http://creativecommons.org/licenses/by-nc/4.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Original Article Nam, Ji Sun Han, Jung Woo Lee, Sang Bae You, Ji Hong Kim, Min Jin Kang, Shinae Park, Jong Suk Ahn, Chul Woo Calpain-10 and Adiponectin Gene Polymorphisms in Korean Type 2 Diabetes Patients |
title | Calpain-10 and Adiponectin Gene Polymorphisms in Korean Type 2 Diabetes Patients |
title_full | Calpain-10 and Adiponectin Gene Polymorphisms in Korean Type 2 Diabetes Patients |
title_fullStr | Calpain-10 and Adiponectin Gene Polymorphisms in Korean Type 2 Diabetes Patients |
title_full_unstemmed | Calpain-10 and Adiponectin Gene Polymorphisms in Korean Type 2 Diabetes Patients |
title_short | Calpain-10 and Adiponectin Gene Polymorphisms in Korean Type 2 Diabetes Patients |
title_sort | calpain-10 and adiponectin gene polymorphisms in korean type 2 diabetes patients |
topic | Original Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6145956/ https://www.ncbi.nlm.nih.gov/pubmed/30229575 http://dx.doi.org/10.3803/EnM.2018.33.3.364 |
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