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Boldine Ameliorates Estrogen Deficiency-Induced Bone Loss via Inhibiting Bone Resorption
Osteoporosis is an enormous health problem caused by the imbalance between bone resorption and bone formation. The current therapeutic strategies for osteoporosis still have some limitations. Boldine, an alkaloid isolated from Peumus boldus, has been shown to have antioxidant and anti-inflammatory e...
Autores principales: | , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6146032/ https://www.ncbi.nlm.nih.gov/pubmed/30271347 http://dx.doi.org/10.3389/fphar.2018.01046 |
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author | Chen, Kun Lv, Zheng-tao Cheng, Peng Zhu, Wen-tao Liang, Shuang Yang, Qing Parkman, Virginia-Jeni Akila Zhou, Chen-he Jing, Xing-zhi Liu, Hui Wang, Yu-ting Lin, Hui Liao, Hui Chen, An-min |
author_facet | Chen, Kun Lv, Zheng-tao Cheng, Peng Zhu, Wen-tao Liang, Shuang Yang, Qing Parkman, Virginia-Jeni Akila Zhou, Chen-he Jing, Xing-zhi Liu, Hui Wang, Yu-ting Lin, Hui Liao, Hui Chen, An-min |
author_sort | Chen, Kun |
collection | PubMed |
description | Osteoporosis is an enormous health problem caused by the imbalance between bone resorption and bone formation. The current therapeutic strategies for osteoporosis still have some limitations. Boldine, an alkaloid isolated from Peumus boldus, has been shown to have antioxidant and anti-inflammatory effects in vivo. For the first time, we discover that boldine has a protective effect for the estrogen deficiency-induced bone loss in mice. According to the Micro-CT and histomorphometry assays, boldine conducts this protective effect through inhibiting bone resorption without affecting bone formation in vivo. Moreover, we showed that boldine can inhibit receptor activator of nuclear factor-κB ligand (RANKL)-induced osteoclast formation via impairing the AKT signaling pathways, while SC79 (an AKT agonist) partially rescue this effect. In conclusion, our results suggest that boldine can prevent estrogen deficiency-induced osteoporosis by inhibiting osteoclastogenesis. Thus, boldine may be served as a novel therapeutic agent for anti-osteoporotic therapy. |
format | Online Article Text |
id | pubmed-6146032 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2018 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-61460322018-09-28 Boldine Ameliorates Estrogen Deficiency-Induced Bone Loss via Inhibiting Bone Resorption Chen, Kun Lv, Zheng-tao Cheng, Peng Zhu, Wen-tao Liang, Shuang Yang, Qing Parkman, Virginia-Jeni Akila Zhou, Chen-he Jing, Xing-zhi Liu, Hui Wang, Yu-ting Lin, Hui Liao, Hui Chen, An-min Front Pharmacol Pharmacology Osteoporosis is an enormous health problem caused by the imbalance between bone resorption and bone formation. The current therapeutic strategies for osteoporosis still have some limitations. Boldine, an alkaloid isolated from Peumus boldus, has been shown to have antioxidant and anti-inflammatory effects in vivo. For the first time, we discover that boldine has a protective effect for the estrogen deficiency-induced bone loss in mice. According to the Micro-CT and histomorphometry assays, boldine conducts this protective effect through inhibiting bone resorption without affecting bone formation in vivo. Moreover, we showed that boldine can inhibit receptor activator of nuclear factor-κB ligand (RANKL)-induced osteoclast formation via impairing the AKT signaling pathways, while SC79 (an AKT agonist) partially rescue this effect. In conclusion, our results suggest that boldine can prevent estrogen deficiency-induced osteoporosis by inhibiting osteoclastogenesis. Thus, boldine may be served as a novel therapeutic agent for anti-osteoporotic therapy. Frontiers Media S.A. 2018-09-13 /pmc/articles/PMC6146032/ /pubmed/30271347 http://dx.doi.org/10.3389/fphar.2018.01046 Text en Copyright © 2018 Chen, Lv, Cheng, Zhu, Liang, Yang, Parkman, Zhou, Jing, Liu, Wang, Lin, Liao and Chen. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Pharmacology Chen, Kun Lv, Zheng-tao Cheng, Peng Zhu, Wen-tao Liang, Shuang Yang, Qing Parkman, Virginia-Jeni Akila Zhou, Chen-he Jing, Xing-zhi Liu, Hui Wang, Yu-ting Lin, Hui Liao, Hui Chen, An-min Boldine Ameliorates Estrogen Deficiency-Induced Bone Loss via Inhibiting Bone Resorption |
title | Boldine Ameliorates Estrogen Deficiency-Induced Bone Loss via Inhibiting Bone Resorption |
title_full | Boldine Ameliorates Estrogen Deficiency-Induced Bone Loss via Inhibiting Bone Resorption |
title_fullStr | Boldine Ameliorates Estrogen Deficiency-Induced Bone Loss via Inhibiting Bone Resorption |
title_full_unstemmed | Boldine Ameliorates Estrogen Deficiency-Induced Bone Loss via Inhibiting Bone Resorption |
title_short | Boldine Ameliorates Estrogen Deficiency-Induced Bone Loss via Inhibiting Bone Resorption |
title_sort | boldine ameliorates estrogen deficiency-induced bone loss via inhibiting bone resorption |
topic | Pharmacology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6146032/ https://www.ncbi.nlm.nih.gov/pubmed/30271347 http://dx.doi.org/10.3389/fphar.2018.01046 |
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