Drug Target Commons 2.0: a community platform for systematic analysis of drug–target interaction profiles

Drug Target Commons (DTC) is a web platform (database with user interface) for community-driven bioactivity data integration and standardization for comprehensive mapping, reuse and analysis of compound–target interaction profiles. End users can search, upload, edit, annotate and export expert-curat...

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Detalles Bibliográficos
Autores principales: Tanoli, ZiaurRehman, Alam, Zaid, Vähä-Koskela, Markus, Ravikumar, Balaguru, Malyutina, Alina, Jaiswal, Alok, Tang, Jing, Wennerberg, Krister, Aittokallio, Tero
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2018
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6146131/
https://www.ncbi.nlm.nih.gov/pubmed/30219839
http://dx.doi.org/10.1093/database/bay083
Descripción
Sumario:Drug Target Commons (DTC) is a web platform (database with user interface) for community-driven bioactivity data integration and standardization for comprehensive mapping, reuse and analysis of compound–target interaction profiles. End users can search, upload, edit, annotate and export expert-curated bioactivity data for further analysis, using an application programmable interface, database dump or tab-delimited text download options. To guide chemical biology and drug-repurposing applications, DTC version 2.0 includes updated clinical development information for the compounds and target gene–disease associations, as well as cancer-type indications for mutant protein targets, which are critical for precision oncology developments.

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