Drug Target Commons 2.0: a community platform for systematic analysis of drug–target interaction profiles

Drug Target Commons (DTC) is a web platform (database with user interface) for community-driven bioactivity data integration and standardization for comprehensive mapping, reuse and analysis of compound–target interaction profiles. End users can search, upload, edit, annotate and export expert-curat...

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Detalles Bibliográficos
Autores principales: Tanoli, ZiaurRehman, Alam, Zaid, Vähä-Koskela, Markus, Ravikumar, Balaguru, Malyutina, Alina, Jaiswal, Alok, Tang, Jing, Wennerberg, Krister, Aittokallio, Tero
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2018
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6146131/
https://www.ncbi.nlm.nih.gov/pubmed/30219839
http://dx.doi.org/10.1093/database/bay083
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author Tanoli, ZiaurRehman
Alam, Zaid
Vähä-Koskela, Markus
Ravikumar, Balaguru
Malyutina, Alina
Jaiswal, Alok
Tang, Jing
Wennerberg, Krister
Aittokallio, Tero
author_facet Tanoli, ZiaurRehman
Alam, Zaid
Vähä-Koskela, Markus
Ravikumar, Balaguru
Malyutina, Alina
Jaiswal, Alok
Tang, Jing
Wennerberg, Krister
Aittokallio, Tero
author_sort Tanoli, ZiaurRehman
collection PubMed
description Drug Target Commons (DTC) is a web platform (database with user interface) for community-driven bioactivity data integration and standardization for comprehensive mapping, reuse and analysis of compound–target interaction profiles. End users can search, upload, edit, annotate and export expert-curated bioactivity data for further analysis, using an application programmable interface, database dump or tab-delimited text download options. To guide chemical biology and drug-repurposing applications, DTC version 2.0 includes updated clinical development information for the compounds and target gene–disease associations, as well as cancer-type indications for mutant protein targets, which are critical for precision oncology developments.
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spelling pubmed-61461312018-09-25 Drug Target Commons 2.0: a community platform for systematic analysis of drug–target interaction profiles Tanoli, ZiaurRehman Alam, Zaid Vähä-Koskela, Markus Ravikumar, Balaguru Malyutina, Alina Jaiswal, Alok Tang, Jing Wennerberg, Krister Aittokallio, Tero Database (Oxford) Original Article Drug Target Commons (DTC) is a web platform (database with user interface) for community-driven bioactivity data integration and standardization for comprehensive mapping, reuse and analysis of compound–target interaction profiles. End users can search, upload, edit, annotate and export expert-curated bioactivity data for further analysis, using an application programmable interface, database dump or tab-delimited text download options. To guide chemical biology and drug-repurposing applications, DTC version 2.0 includes updated clinical development information for the compounds and target gene–disease associations, as well as cancer-type indications for mutant protein targets, which are critical for precision oncology developments. Oxford University Press 2018-09-13 /pmc/articles/PMC6146131/ /pubmed/30219839 http://dx.doi.org/10.1093/database/bay083 Text en © The Author(s) 2018. Published by Oxford University Press. http://creativecommons.org/licenses/by/4.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Original Article
Tanoli, ZiaurRehman
Alam, Zaid
Vähä-Koskela, Markus
Ravikumar, Balaguru
Malyutina, Alina
Jaiswal, Alok
Tang, Jing
Wennerberg, Krister
Aittokallio, Tero
Drug Target Commons 2.0: a community platform for systematic analysis of drug–target interaction profiles
title Drug Target Commons 2.0: a community platform for systematic analysis of drug–target interaction profiles
title_full Drug Target Commons 2.0: a community platform for systematic analysis of drug–target interaction profiles
title_fullStr Drug Target Commons 2.0: a community platform for systematic analysis of drug–target interaction profiles
title_full_unstemmed Drug Target Commons 2.0: a community platform for systematic analysis of drug–target interaction profiles
title_short Drug Target Commons 2.0: a community platform for systematic analysis of drug–target interaction profiles
title_sort drug target commons 2.0: a community platform for systematic analysis of drug–target interaction profiles
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6146131/
https://www.ncbi.nlm.nih.gov/pubmed/30219839
http://dx.doi.org/10.1093/database/bay083
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