Role of genetic and environmental factors in DNA methylation of lipid metabolism

A number of recent studies revealed that DNA methylation plays a central role in the regulation of lipid metabolism. DNA methylation modifications are important regulators of transcriptional networks that do not affect the DNA sequence and can translate genetic variants and environmental factors int...

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Autores principales: He, Zhen, Zhang, Rong, Jiang, Feng, Hou, Wenjing, Hu, Cheng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Chongqing Medical University 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6146210/
https://www.ncbi.nlm.nih.gov/pubmed/30258929
http://dx.doi.org/10.1016/j.gendis.2017.11.005
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author He, Zhen
Zhang, Rong
Jiang, Feng
Hou, Wenjing
Hu, Cheng
author_facet He, Zhen
Zhang, Rong
Jiang, Feng
Hou, Wenjing
Hu, Cheng
author_sort He, Zhen
collection PubMed
description A number of recent studies revealed that DNA methylation plays a central role in the regulation of lipid metabolism. DNA methylation modifications are important regulators of transcriptional networks that do not affect the DNA sequence and can translate genetic variants and environmental factors into phenotypic traits. Therefore, elucidating the factors that underlie inter-individual DNA methylation variations gives us an opportunity to predict diseases and interfere with the establishment of aberrant DNA methylation early. In this review, we summarize the findings of DNA methylation-related studies focused on unravelling the potential role of genetic and environmental factors in DNA methylation and the regulatory effect of DNA methylation on gene expression in lipid metabolism.
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spelling pubmed-61462102018-09-26 Role of genetic and environmental factors in DNA methylation of lipid metabolism He, Zhen Zhang, Rong Jiang, Feng Hou, Wenjing Hu, Cheng Genes Dis Article A number of recent studies revealed that DNA methylation plays a central role in the regulation of lipid metabolism. DNA methylation modifications are important regulators of transcriptional networks that do not affect the DNA sequence and can translate genetic variants and environmental factors into phenotypic traits. Therefore, elucidating the factors that underlie inter-individual DNA methylation variations gives us an opportunity to predict diseases and interfere with the establishment of aberrant DNA methylation early. In this review, we summarize the findings of DNA methylation-related studies focused on unravelling the potential role of genetic and environmental factors in DNA methylation and the regulatory effect of DNA methylation on gene expression in lipid metabolism. Chongqing Medical University 2017-11-24 /pmc/articles/PMC6146210/ /pubmed/30258929 http://dx.doi.org/10.1016/j.gendis.2017.11.005 Text en © 2017 Chongqing Medical University. Production and hosting by Elsevier B.V. http://creativecommons.org/licenses/by-nc-nd/4.0/ This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Article
He, Zhen
Zhang, Rong
Jiang, Feng
Hou, Wenjing
Hu, Cheng
Role of genetic and environmental factors in DNA methylation of lipid metabolism
title Role of genetic and environmental factors in DNA methylation of lipid metabolism
title_full Role of genetic and environmental factors in DNA methylation of lipid metabolism
title_fullStr Role of genetic and environmental factors in DNA methylation of lipid metabolism
title_full_unstemmed Role of genetic and environmental factors in DNA methylation of lipid metabolism
title_short Role of genetic and environmental factors in DNA methylation of lipid metabolism
title_sort role of genetic and environmental factors in dna methylation of lipid metabolism
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6146210/
https://www.ncbi.nlm.nih.gov/pubmed/30258929
http://dx.doi.org/10.1016/j.gendis.2017.11.005
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