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Combinatorial use of disulfide bridges and native sulfur-SAD phasing for rapid structure determination of coiled-coils

Coiled-coils are ubiquitous protein–protein interaction motifs found in many eukaryotic proteins. The elongated, flexible and often irregular nature of coiled-coils together with their tendency to form fibrous arrangements in crystals imposes challenges on solving the phase problem by molecular repl...

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Detalles Bibliográficos
Autores principales: Kraatz, Sebastian H.W., Bianchi, Sarah, Steinmetz, Michel O.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Portland Press Ltd. 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6146289/
https://www.ncbi.nlm.nih.gov/pubmed/30135143
http://dx.doi.org/10.1042/BSR20181073