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The association between MMP-1 gene rs1799750 polymorphism and knee osteoarthritis risk
Matrix metalloproteinase 1 (MMP-1) degrades cartilage, which may result in osteoarthritis (OA) development. Several studies have explored the association between MMP-1 gene rs1799750 polymorphism and OA in different populations. However, the results are inconsistent. The aim of this case–control stu...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Portland Press Ltd.
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6146290/ https://www.ncbi.nlm.nih.gov/pubmed/30177524 http://dx.doi.org/10.1042/BSR20181257 |
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author | Geng, Rui Xu, Yuansheng Hu, Wenhao Zhao, Hui |
author_facet | Geng, Rui Xu, Yuansheng Hu, Wenhao Zhao, Hui |
author_sort | Geng, Rui |
collection | PubMed |
description | Matrix metalloproteinase 1 (MMP-1) degrades cartilage, which may result in osteoarthritis (OA) development. Several studies have explored the association between MMP-1 gene rs1799750 polymorphism and OA in different populations. However, the results are inconsistent. The aim of this case–control study was to investigate the association between MMP-1 gene rs1799750 polymorphism and knee OA in a Chinese population. The present study included 308 cases and 404 controls. Genotyping was performed using standard polymerase chain reaction and restriction fragment length polymorphism. The present study found that 2G2G genotype (2G2G vs 1G1G: OR & 95% CI, 2.28 (1.47–3.53), P<0.001; 2G2G + 1G2G vs 1G1G: OR & 95% CI, 1.61 (1.15–2.24), P=0.005; 2G2G vs 1G2G + 1G1G: OR & 95% CI, 1.84 (1.26–2.68), P=0.002) or 2G allele carriers (2G vs 1G: OR & 95% CI, 1.48 (1.20–1.83), P<0.001) of MMP-1 gene rs1799750 polymorphism increased the risk of OA. In conclusion, this case–control study confirms that MMP-1 gene rs1799750 polymorphism increases the risk of knee OA in Chinese Han population. |
format | Online Article Text |
id | pubmed-6146290 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2018 |
publisher | Portland Press Ltd. |
record_format | MEDLINE/PubMed |
spelling | pubmed-61462902018-09-25 The association between MMP-1 gene rs1799750 polymorphism and knee osteoarthritis risk Geng, Rui Xu, Yuansheng Hu, Wenhao Zhao, Hui Biosci Rep Research Articles Matrix metalloproteinase 1 (MMP-1) degrades cartilage, which may result in osteoarthritis (OA) development. Several studies have explored the association between MMP-1 gene rs1799750 polymorphism and OA in different populations. However, the results are inconsistent. The aim of this case–control study was to investigate the association between MMP-1 gene rs1799750 polymorphism and knee OA in a Chinese population. The present study included 308 cases and 404 controls. Genotyping was performed using standard polymerase chain reaction and restriction fragment length polymorphism. The present study found that 2G2G genotype (2G2G vs 1G1G: OR & 95% CI, 2.28 (1.47–3.53), P<0.001; 2G2G + 1G2G vs 1G1G: OR & 95% CI, 1.61 (1.15–2.24), P=0.005; 2G2G vs 1G2G + 1G1G: OR & 95% CI, 1.84 (1.26–2.68), P=0.002) or 2G allele carriers (2G vs 1G: OR & 95% CI, 1.48 (1.20–1.83), P<0.001) of MMP-1 gene rs1799750 polymorphism increased the risk of OA. In conclusion, this case–control study confirms that MMP-1 gene rs1799750 polymorphism increases the risk of knee OA in Chinese Han population. Portland Press Ltd. 2018-09-19 /pmc/articles/PMC6146290/ /pubmed/30177524 http://dx.doi.org/10.1042/BSR20181257 Text en © 2018 The Author(s). http://creativecommons.org/licenses/by/4.0/This is an open access article published by Portland Press Limited on behalf of the Biochemical Society and distributed under the Creative Commons Attribution License 4.0 (CC BY) (http://creativecommons.org/licenses/by/4.0/) . |
spellingShingle | Research Articles Geng, Rui Xu, Yuansheng Hu, Wenhao Zhao, Hui The association between MMP-1 gene rs1799750 polymorphism and knee osteoarthritis risk |
title | The association between MMP-1 gene rs1799750 polymorphism and knee osteoarthritis risk |
title_full | The association between MMP-1 gene rs1799750 polymorphism and knee osteoarthritis risk |
title_fullStr | The association between MMP-1 gene rs1799750 polymorphism and knee osteoarthritis risk |
title_full_unstemmed | The association between MMP-1 gene rs1799750 polymorphism and knee osteoarthritis risk |
title_short | The association between MMP-1 gene rs1799750 polymorphism and knee osteoarthritis risk |
title_sort | association between mmp-1 gene rs1799750 polymorphism and knee osteoarthritis risk |
topic | Research Articles |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6146290/ https://www.ncbi.nlm.nih.gov/pubmed/30177524 http://dx.doi.org/10.1042/BSR20181257 |
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