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The association between MMP-1 gene rs1799750 polymorphism and knee osteoarthritis risk

Matrix metalloproteinase 1 (MMP-1) degrades cartilage, which may result in osteoarthritis (OA) development. Several studies have explored the association between MMP-1 gene rs1799750 polymorphism and OA in different populations. However, the results are inconsistent. The aim of this case–control stu...

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Autores principales: Geng, Rui, Xu, Yuansheng, Hu, Wenhao, Zhao, Hui
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Portland Press Ltd. 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6146290/
https://www.ncbi.nlm.nih.gov/pubmed/30177524
http://dx.doi.org/10.1042/BSR20181257
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author Geng, Rui
Xu, Yuansheng
Hu, Wenhao
Zhao, Hui
author_facet Geng, Rui
Xu, Yuansheng
Hu, Wenhao
Zhao, Hui
author_sort Geng, Rui
collection PubMed
description Matrix metalloproteinase 1 (MMP-1) degrades cartilage, which may result in osteoarthritis (OA) development. Several studies have explored the association between MMP-1 gene rs1799750 polymorphism and OA in different populations. However, the results are inconsistent. The aim of this case–control study was to investigate the association between MMP-1 gene rs1799750 polymorphism and knee OA in a Chinese population. The present study included 308 cases and 404 controls. Genotyping was performed using standard polymerase chain reaction and restriction fragment length polymorphism. The present study found that 2G2G genotype (2G2G vs 1G1G: OR & 95% CI, 2.28 (1.47–3.53), P<0.001; 2G2G + 1G2G vs 1G1G: OR & 95% CI, 1.61 (1.15–2.24), P=0.005; 2G2G vs 1G2G + 1G1G: OR & 95% CI, 1.84 (1.26–2.68), P=0.002) or 2G allele carriers (2G vs 1G: OR & 95% CI, 1.48 (1.20–1.83), P<0.001) of MMP-1 gene rs1799750 polymorphism increased the risk of OA. In conclusion, this case–control study confirms that MMP-1 gene rs1799750 polymorphism increases the risk of knee OA in Chinese Han population.
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spelling pubmed-61462902018-09-25 The association between MMP-1 gene rs1799750 polymorphism and knee osteoarthritis risk Geng, Rui Xu, Yuansheng Hu, Wenhao Zhao, Hui Biosci Rep Research Articles Matrix metalloproteinase 1 (MMP-1) degrades cartilage, which may result in osteoarthritis (OA) development. Several studies have explored the association between MMP-1 gene rs1799750 polymorphism and OA in different populations. However, the results are inconsistent. The aim of this case–control study was to investigate the association between MMP-1 gene rs1799750 polymorphism and knee OA in a Chinese population. The present study included 308 cases and 404 controls. Genotyping was performed using standard polymerase chain reaction and restriction fragment length polymorphism. The present study found that 2G2G genotype (2G2G vs 1G1G: OR & 95% CI, 2.28 (1.47–3.53), P<0.001; 2G2G + 1G2G vs 1G1G: OR & 95% CI, 1.61 (1.15–2.24), P=0.005; 2G2G vs 1G2G + 1G1G: OR & 95% CI, 1.84 (1.26–2.68), P=0.002) or 2G allele carriers (2G vs 1G: OR & 95% CI, 1.48 (1.20–1.83), P<0.001) of MMP-1 gene rs1799750 polymorphism increased the risk of OA. In conclusion, this case–control study confirms that MMP-1 gene rs1799750 polymorphism increases the risk of knee OA in Chinese Han population. Portland Press Ltd. 2018-09-19 /pmc/articles/PMC6146290/ /pubmed/30177524 http://dx.doi.org/10.1042/BSR20181257 Text en © 2018 The Author(s). http://creativecommons.org/licenses/by/4.0/This is an open access article published by Portland Press Limited on behalf of the Biochemical Society and distributed under the Creative Commons Attribution License 4.0 (CC BY) (http://creativecommons.org/licenses/by/4.0/) .
spellingShingle Research Articles
Geng, Rui
Xu, Yuansheng
Hu, Wenhao
Zhao, Hui
The association between MMP-1 gene rs1799750 polymorphism and knee osteoarthritis risk
title The association between MMP-1 gene rs1799750 polymorphism and knee osteoarthritis risk
title_full The association between MMP-1 gene rs1799750 polymorphism and knee osteoarthritis risk
title_fullStr The association between MMP-1 gene rs1799750 polymorphism and knee osteoarthritis risk
title_full_unstemmed The association between MMP-1 gene rs1799750 polymorphism and knee osteoarthritis risk
title_short The association between MMP-1 gene rs1799750 polymorphism and knee osteoarthritis risk
title_sort association between mmp-1 gene rs1799750 polymorphism and knee osteoarthritis risk
topic Research Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6146290/
https://www.ncbi.nlm.nih.gov/pubmed/30177524
http://dx.doi.org/10.1042/BSR20181257
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