Serum and glucocorticoid inducible protein kinases (SGKs): a potential target for cancer intervention

The serum and glucocorticoid inducible protein kinase (SGK) family members share similar structure, substrate specificity and function with AKT and signal downstream of the phosphatidylinositol 3-kinase (PI3K) signalling pathway. They regulate a range of fundamental cellular processes such as cell p...

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Detalles Bibliográficos
Autores principales: Basnet, Rajesh, Gong, Grace Qun, Li, Chenyao, Wang, Ming-Wei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2018
Materias:
Perspective
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6146383/
https://www.ncbi.nlm.nih.gov/pubmed/30245963
http://dx.doi.org/10.1016/j.apsb.2018.07.001
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author Basnet, Rajesh
Gong, Grace Qun
Li, Chenyao
Wang, Ming-Wei
author_facet Basnet, Rajesh
Gong, Grace Qun
Li, Chenyao
Wang, Ming-Wei
author_sort Basnet, Rajesh
collection PubMed
description The serum and glucocorticoid inducible protein kinase (SGK) family members share similar structure, substrate specificity and function with AKT and signal downstream of the phosphatidylinositol 3-kinase (PI3K) signalling pathway. They regulate a range of fundamental cellular processes such as cell proliferation and survival, thereby playing an important role in cancer development. This perspective intends to give an overview on the involvement of SGKs (particularly SGK3) in cancer progression, and compares the actions of SGK3 and AKT in cell cycle regulation, oncogenic signalling, and the potential as a therapeutic target for cancer.
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spelling pubmed-61463832018-09-21 Serum and glucocorticoid inducible protein kinases (SGKs): a potential target for cancer intervention Basnet, Rajesh Gong, Grace Qun Li, Chenyao Wang, Ming-Wei Acta Pharm Sin B Perspective The serum and glucocorticoid inducible protein kinase (SGK) family members share similar structure, substrate specificity and function with AKT and signal downstream of the phosphatidylinositol 3-kinase (PI3K) signalling pathway. They regulate a range of fundamental cellular processes such as cell proliferation and survival, thereby playing an important role in cancer development. This perspective intends to give an overview on the involvement of SGKs (particularly SGK3) in cancer progression, and compares the actions of SGK3 and AKT in cell cycle regulation, oncogenic signalling, and the potential as a therapeutic target for cancer. Elsevier 2018-09 2018-07-05 /pmc/articles/PMC6146383/ /pubmed/30245963 http://dx.doi.org/10.1016/j.apsb.2018.07.001 Text en © 2018 Chinese Pharmaceutical Association and Institute of Materia Medica, Chinese Academy of Medical Sciences. Production and hosting by Elsevier B.V. http://creativecommons.org/licenses/by-nc-nd/4.0/ This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Perspective
Basnet, Rajesh
Gong, Grace Qun
Li, Chenyao
Wang, Ming-Wei
Serum and glucocorticoid inducible protein kinases (SGKs): a potential target for cancer intervention
title Serum and glucocorticoid inducible protein kinases (SGKs): a potential target for cancer intervention
title_full Serum and glucocorticoid inducible protein kinases (SGKs): a potential target for cancer intervention
title_fullStr Serum and glucocorticoid inducible protein kinases (SGKs): a potential target for cancer intervention
title_full_unstemmed Serum and glucocorticoid inducible protein kinases (SGKs): a potential target for cancer intervention
title_short Serum and glucocorticoid inducible protein kinases (SGKs): a potential target for cancer intervention
title_sort serum and glucocorticoid inducible protein kinases (sgks): a potential target for cancer intervention
topic Perspective
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6146383/
https://www.ncbi.nlm.nih.gov/pubmed/30245963
http://dx.doi.org/10.1016/j.apsb.2018.07.001
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