Cargando…

Synthesis and Biological Activity of 3-(2-Furanyl)-6-Aryl-1,2,4-Triazolo[3,4-b]-1,3,4 –Thiadiazoles

3-(2-Furanyl)-4-amino-5-mercapto-1,2,4-triazole (1) was prepared from 2-furoic acid through a multi-step reaction sequence. Compound 1 reacted with aromatic acids in the presence of phosphorus oxychloride to give 3-(2-furanyl)-6-aryl-1,2,4- triazolo[3,4-b]-1,3,4-thiadiazoles (2). The structures of a...

Descripción completa

Detalles Bibliográficos
Autores principales:	Zhang, Li-Xue, Zhang, An-Jiang, Chen, Xian-Xing, Lei, Xin-Xiang, Nan, Xiang-Yun, Chen, Dong-Yong, Zhang, Zi-Yi
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2002
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6146422/ http://dx.doi.org/10.3390/70800681

Ejemplares similares

3-Methyl-6-trichloromethyl-1,2,4-triazolo[3,4-b][1,3,4]thiadiazole
por: Jia, Wei-min, et al.
Publicado: (2011)

3,6-Bis(3,4,5-trimethoxyphenyl)-1,2,4-triazolo[3,4-b][1,3,4]thiadiazole
por: Du, Hai-Tang, et al.
Publicado: (2008)

6-(1-Adamantyl)-3-(2-fluorophenyl)-1,2,4-triazolo[3,4-b][1,3,4]thiadiazole
por: Khan, Mahmood-ul-Hassan, et al.
Publicado: (2009)

6-(1-Adamantyl)-3-(2-chlorophenyl)-1,2,4-triazolo[3,4-b][1,3,4]thiadiazole
por: Tahir, M. Nawaz, et al.
Publicado: (2011)

6-(Adamantan-1-yl)-3-(3-fluorophenyl)-1,2,4-triazolo[3,4-b][1,3,4]thiadiazole
por: Khan, Mahmood-ul-Hassan, et al.
Publicado: (2010)

3-(2-Fluorophenyl)-6-(phenoxymethyl)-1,2,4-triazolo[3,4-b][1,3,4]thiadiazole
por: Holm, Melanie, et al.
Publicado: (2008)

6-(4-Methylphenyl)-3-(3,4,5-trimethoxyphenyl)-1,2,4-triazolo[3,4-b][1,3,4]thiadiazole
por: Du, Hai-Tang, et al.
Publicado: (2008)

6-(4-Pyridyl)-3-(3,4,5-trimethoxyphenyl)-1,2,4-triazolo[3,4-b][1,3,4]thiadiazole
por: Du, Hai-Tang, et al.
Publicado: (2008)

6-(3-Pyridyl)-3-(3,4,5-trimethoxyphenyl)-1,2,4-triazolo[3,4-b][1,3,4]thiadiazole
por: Du, Haitang, et al.
Publicado: (2008)

Ethyl 5-[6-(furan-2-yl)-1,2,4-triazolo[3,4-b][1,3,4]thiadiazol-3-yl]-2,6-dimethylnicotinate
por: Lu, Dongliang, et al.
Publicado: (2007)

Novel [1,2,4]triazolo[3,4-b][1,3,4]thiadiazine and [1,2,4]triazolo[3,4-b][1,3,4]thiadiazepine Derivatives: Synthesis, Anti-Viral In Vitro Study and Target Validation Activity
por: Khramchikhin, Andrey V., et al.
Publicado: (2022)

6-(2-Methylphenyl)-3-(3,4,5-trimethoxyphenyl)-1,2,4-triazolo[3,4-b][1,3,4]thiadiazole
por: Du, Haitang, et al.
Publicado: (2008)

3-Ethyl-6-[3-(4-fluorophenyl)-1H-pyrazol-4-yl]-1,2,4-triazolo[3,4-b][1,3,4]thiadiazole
por: Fun, Hoong-Kun, et al.
Publicado: (2010)

4-Bromobenzoic acid–6-(4-bromophenyl)-3-methyl-1,2,4-triazolo[3,4-b][1,3,4]thiadiazole (1/1)
por: Kapoor, Kamini, et al.
Publicado: (2012)

3-Ethyl-6-{1-[4-(2-methylpropyl)phenyl]ethyl}-1,2,4-triazolo[3,4-b][1,3,4]thiadiazole
por: Fun, Hoong-Kun, et al.
Publicado: (2008)

3-[1-(4-Isobutylphenyl)ethyl]-6-(4-methylphenyl)-1,2,4-triazolo[3,4-b][1,3,4]thiadiazole
por: Fun, Hoong-Kun, et al.
Publicado: (2008)

Synthesis under Microwave Irradiation of [1,2,4]Triazolo[3,4-b][1,3,4]thiadiazoles and Other Diazoles Bearing Indole Moieties and Their Antimicrobial Evaluation
por: Gomha, Sobhi M., et al.
Publicado: (2011)

Crystal structure of 3-benzylsulfanyl-6-(5-methyl-1,2-oxazol-3-yl)-1,2,4-triazolo[3,4-b][1,3,4]thiadiazole
por: Vaarla, Krishnaiah, et al.
Publicado: (2015)

Vision on Synthetic and Medicinal Facets of 1,2,4-Triazolo[3,4-b][1,3,4]thiadiazine Scaffold
por: Aggarwal, Ranjana, et al.
Publicado: (2022)

3,6-Disubstituted 1,2,4-Triazolo[3,4-b]Thiadiazoles with Anticancer Activity Targeting Topoisomerase II Alpha
por: Sagredou, Sofia, et al.
Publicado: (2020)

[1,2,4]triazolo[3,4-b][1,3,4]thiadiazole derivatives as new therapeutic candidates against urease positive microorganisms: design, synthesis, pharmacological evaluations, and in silico studies
por: Khalili Ghomi, Minoo, et al.
Publicado: (2023)

3-Methyl-1,2,4-triazolo[3,4-a]phthalazine monohydrate
por: Dutkiewicz, Grzegorz, et al.
Publicado: (2009)

Synthesis and antimicrobial activity of some novel fused heterocyclic 1,2,4-triazolo [3,4-b][1,3,4] thiadiazine derivatives
por: Sahu, Jagdish K., et al.
Publicado: (2014)

3-Ethyl-6-(4-fluorophenyl)-7H-1,2,4-triazolo[3,4-b][1,3,4]thiadiazine
por: Jeyaseelan, S., et al.
Publicado: (2012)

6-(4-Bromophenyl)-3-methyl-7H-1,2,4-triazolo[3,4-b][1,3,4]thiadiazine
por: Fun, Hoong-Kun, et al.
Publicado: (2012)

Synthesis of Novel 2,5-Disubstituted-1,3,4-thiadiazoles Clubbed 1,2,4-Triazole, 1,3,4-Thiadiazole, 1,3,4-Oxadiazole and/or Schiff Base as Potential Antimicrobial and Antiproliferative Agents
por: Rezki, Nadjet, et al.
Publicado: (2015)

2-(6-Phenyl-7H-1,2,4-triazolo[3,4-b][1,3,4]thiadiazin-3-yl)-1,3-benzothiazole
por: Abdel-Aziz, Hatem A., et al.
Publicado: (2011)

6-(4-Fluorophenyl)-3-phenyl-7H-1,2,4-triazolo[3,4-b][1,3,4]thiadiazine
por: Palakshamurthy, B. S., et al.
Publicado: (2014)

Design, Synthesis, and Biological Evaluation of Novel 7H-[1,2,4]Triazolo[3,4-b][1,3,4]thiadiazine Inhibitors as Antitumor Agents
por: Ismail, Muhammad I., et al.
Publicado: (2020)

Structural and Energetic Properties of Weak Noncovalent Interactions in Two Closely Related 3,6-Disubstituted-[1,2,4]triazolo[3,4-b][1,3,4]thiadiazole Derivatives: In Vitro Cyclooxygenase Activity, Crystallography, and Computational Investigations
por: Al-Wahaibi, Lamya H., et al.
Publicado: (2022)

4-(5-Phenyl-1,2,4-triazolo[3,4-a]isoquinolin-3-yl)benzonitrile
por: Khan, F. Nawaz, et al.
Publicado: (2010)

Design, synthesis and structure-activity relationship of 3,6-diaryl-7H-[1,2,4]triazolo[3,4-b][1,3,4]thiadiazines as novel tubulin inhibitors
por: Xu, Qile, et al.
Publicado: (2017)

5-Phenyl-3-(2-thienyl)-1,2,4-triazolo[3,4-a]isoquinoline
por: Khan, F. Nawaz, et al.
Publicado: (2010)

Synthesis and antimicrobial evaluation of some novel 1,2,4-triazole and 1,3,4-thiadiazole derivatives
por: Popiołek, Łukasz, et al.
Publicado: (2012)

4-[3-(1-Naphthyloxymethyl)-7H-1,2,4-triazolo[3,4-b][1,3,4]thiadiazin-6-yl]-3-p-tolylsydnone
por: Goh, Jia Hao, et al.
Publicado: (2010)

Electrophilically Activated Nitroalkanes in Double Annulation of [1,2,4]Triazolo[4,3-a]quinolines and 1,3,4-Oxadiazole Rings
por: Aksenov, Alexander V., et al.
Publicado: (2021)

3-(4-Chlorophenyl)-5-phenyl-1,2,4-triazolo[3,4-a]isoquinoline
por: Khan, F. Nawaz, et al.
Publicado: (2010)

3-(4-Hexyloxyphenyl)-1,2,4-triazolo[3,4-b]benzothiazole
por: Schollmeyer, Dieter, et al.
Publicado: (2014)

Synthesis and Bioassay of a New Class of Furanyl-1,3,4-Oxadiazole Derivatives
por: El Sadek, Mohamed M., et al.
Publicado: (2013)

3-Phenyl-4-{3-[(p-tolyloxy)methyl]-7H-1,2,4-triazolo[3,4-b][1,3,4]thiadiazin-6-yl}sydnone
por: Goh, Jia Hao, et al.
Publicado: (2010)

Cannot write session to /tmp/vufind_sessions/sess_6imoeg3vc3e9eqcifp1ahm5fn1