Toward a Library Synthesis of the Natural Dipeptide Antibiotic TAN 1057 A,B

The natural dipeptide antibiotic TAN 1057 A,B represents a promising new antibiotic entity. In this communication we report a novel approach for the synthesis of TAN 1057 A,B analogs bearing variations in the β-arginine side chain. This approach involves a combination of liquid and solid phase metho...

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Detalles Bibliográficos
Autores principales: Aguilar, Nuria, Krüger, Jochen
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2002
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6146428/
http://dx.doi.org/10.3390/70600469
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author Aguilar, Nuria
Krüger, Jochen
author_facet Aguilar, Nuria
Krüger, Jochen
author_sort Aguilar, Nuria
collection PubMed
description The natural dipeptide antibiotic TAN 1057 A,B represents a promising new antibiotic entity. In this communication we report a novel approach for the synthesis of TAN 1057 A,B analogs bearing variations in the β-arginine side chain. This approach involves a combination of liquid and solid phase methods and allows for a library synthesis of analogs of the natural product.
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spelling pubmed-61464282018-11-19 Toward a Library Synthesis of the Natural Dipeptide Antibiotic TAN 1057 A,B Aguilar, Nuria Krüger, Jochen Molecules Article The natural dipeptide antibiotic TAN 1057 A,B represents a promising new antibiotic entity. In this communication we report a novel approach for the synthesis of TAN 1057 A,B analogs bearing variations in the β-arginine side chain. This approach involves a combination of liquid and solid phase methods and allows for a library synthesis of analogs of the natural product. MDPI 2002-06-30 /pmc/articles/PMC6146428/ http://dx.doi.org/10.3390/70600469 Text en © 2002 by MDPI (http://www.mdpi.org). Reproduction is permitted for noncommercial purposes.
spellingShingle Article
Aguilar, Nuria
Krüger, Jochen
Toward a Library Synthesis of the Natural Dipeptide Antibiotic TAN 1057 A,B
title Toward a Library Synthesis of the Natural Dipeptide Antibiotic TAN 1057 A,B
title_full Toward a Library Synthesis of the Natural Dipeptide Antibiotic TAN 1057 A,B
title_fullStr Toward a Library Synthesis of the Natural Dipeptide Antibiotic TAN 1057 A,B
title_full_unstemmed Toward a Library Synthesis of the Natural Dipeptide Antibiotic TAN 1057 A,B
title_short Toward a Library Synthesis of the Natural Dipeptide Antibiotic TAN 1057 A,B
title_sort toward a library synthesis of the natural dipeptide antibiotic tan 1057 a,b
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6146428/
http://dx.doi.org/10.3390/70600469
work_keys_str_mv AT aguilarnuria towardalibrarysynthesisofthenaturaldipeptideantibiotictan1057ab
AT krugerjochen towardalibrarysynthesisofthenaturaldipeptideantibiotictan1057ab

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