Amino Acid Based Synthesis of Chiral Long Chain Diamines and Tetramines

A method for the synthesis of long chain diamines and tetramines starting from natural α-amino acids is reported. Diamines and tetramines were prepared through the Wittig olefination reaction of N-protected amino aldehydes obtained from phenylalanine and lysine. A 1,2,17,18-tetramine was synthesized...

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Autores principales: Loukas, Vassilios, Markidis, Theodoros, Kokotos, George
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2002
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6146442/
http://dx.doi.org/10.3390/71000767
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author Loukas, Vassilios
Markidis, Theodoros
Kokotos, George
author_facet Loukas, Vassilios
Markidis, Theodoros
Kokotos, George
author_sort Loukas, Vassilios
collection PubMed
description A method for the synthesis of long chain diamines and tetramines starting from natural α-amino acids is reported. Diamines and tetramines were prepared through the Wittig olefination reaction of N-protected amino aldehydes obtained from phenylalanine and lysine. A 1,2,17,18-tetramine was synthesized using (2S)-1-azido-2-[bis(tert-butoxycarbonyl)-amino]-5-oxopentane as key-intermediate compound.
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spelling pubmed-61464422018-11-19 Amino Acid Based Synthesis of Chiral Long Chain Diamines and Tetramines Loukas, Vassilios Markidis, Theodoros Kokotos, George Molecules Article A method for the synthesis of long chain diamines and tetramines starting from natural α-amino acids is reported. Diamines and tetramines were prepared through the Wittig olefination reaction of N-protected amino aldehydes obtained from phenylalanine and lysine. A 1,2,17,18-tetramine was synthesized using (2S)-1-azido-2-[bis(tert-butoxycarbonyl)-amino]-5-oxopentane as key-intermediate compound. MDPI 2002-10-31 /pmc/articles/PMC6146442/ http://dx.doi.org/10.3390/71000767 Text en © 2002 by MDPI (http://www.mdpi.org). Reproduction is permitted for noncommercial purposes.
spellingShingle Article
Loukas, Vassilios
Markidis, Theodoros
Kokotos, George
Amino Acid Based Synthesis of Chiral Long Chain Diamines and Tetramines
title Amino Acid Based Synthesis of Chiral Long Chain Diamines and Tetramines
title_full Amino Acid Based Synthesis of Chiral Long Chain Diamines and Tetramines
title_fullStr Amino Acid Based Synthesis of Chiral Long Chain Diamines and Tetramines
title_full_unstemmed Amino Acid Based Synthesis of Chiral Long Chain Diamines and Tetramines
title_short Amino Acid Based Synthesis of Chiral Long Chain Diamines and Tetramines
title_sort amino acid based synthesis of chiral long chain diamines and tetramines
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6146442/
http://dx.doi.org/10.3390/71000767
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AT kokotosgeorge aminoacidbasedsynthesisofchirallongchaindiaminesandtetramines

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