Synthesis of Novel Quinazoline Derivatives via Pyrimidine ortho-Quinodimethane

The [4+2] cycloaddition between 2,4-diphenylpyrimidine ortho-quinodimethane and dimethyl acetylenedicarboxylate leads to 2,4-diphenylquinazoline-6,7-dicarboxylate (6). 2,4-Diphenylfuro[3,4-g]quinazoline-6,8-dione (7) is also obtained by basic hydrolysis of compound 6, followed by the closure of the...

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Autores principales: Chioua, R., Benabdelouahab, F., Chioua, M., Martínez-Alvarez, R., Fernández, A. Herrera
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2002
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6146455/
http://dx.doi.org/10.3390/70700507
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author Chioua, R.
Benabdelouahab, F.
Chioua, M.
Martínez-Alvarez, R.
Fernández, A. Herrera
author_facet Chioua, R.
Benabdelouahab, F.
Chioua, M.
Martínez-Alvarez, R.
Fernández, A. Herrera
author_sort Chioua, R.
collection PubMed
description The [4+2] cycloaddition between 2,4-diphenylpyrimidine ortho-quinodimethane and dimethyl acetylenedicarboxylate leads to 2,4-diphenylquinazoline-6,7-dicarboxylate (6). 2,4-Diphenylfuro[3,4-g]quinazoline-6,8-dione (7) is also obtained by basic hydrolysis of compound 6, followed by the closure of the resulting diacid in acetic anhydride.
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spelling pubmed-61464552018-11-19 Synthesis of Novel Quinazoline Derivatives via Pyrimidine ortho-Quinodimethane Chioua, R. Benabdelouahab, F. Chioua, M. Martínez-Alvarez, R. Fernández, A. Herrera Molecules Article The [4+2] cycloaddition between 2,4-diphenylpyrimidine ortho-quinodimethane and dimethyl acetylenedicarboxylate leads to 2,4-diphenylquinazoline-6,7-dicarboxylate (6). 2,4-Diphenylfuro[3,4-g]quinazoline-6,8-dione (7) is also obtained by basic hydrolysis of compound 6, followed by the closure of the resulting diacid in acetic anhydride. MDPI 2002-07-31 /pmc/articles/PMC6146455/ http://dx.doi.org/10.3390/70700507 Text en © 2002 by MDPI (http://www.mdpi.org). Reproduction is permitted for noncommercial purposes.
spellingShingle Article
Chioua, R.
Benabdelouahab, F.
Chioua, M.
Martínez-Alvarez, R.
Fernández, A. Herrera
Synthesis of Novel Quinazoline Derivatives via Pyrimidine ortho-Quinodimethane
title Synthesis of Novel Quinazoline Derivatives via Pyrimidine ortho-Quinodimethane
title_full Synthesis of Novel Quinazoline Derivatives via Pyrimidine ortho-Quinodimethane
title_fullStr Synthesis of Novel Quinazoline Derivatives via Pyrimidine ortho-Quinodimethane
title_full_unstemmed Synthesis of Novel Quinazoline Derivatives via Pyrimidine ortho-Quinodimethane
title_short Synthesis of Novel Quinazoline Derivatives via Pyrimidine ortho-Quinodimethane
title_sort synthesis of novel quinazoline derivatives via pyrimidine ortho-quinodimethane
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6146455/
http://dx.doi.org/10.3390/70700507
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