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An Efficient Preparation of 1,2-Diamino-1-phenylheptane
A convenient four-step method for the preparation of the lipophilic vicinal diamine 1,2-diamino-1-phenylheptane is described. Condensation involving octan-2-one, benzaldehyde and ammonia is reported. Regioselective Schmidt rearrangement of 2,6-diphenyl-3-pentyl-piperidin-4-one (1) to 2,7-diphenyl-3-...
| Autores principales: | , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
MDPI
2002
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6146457/ http://dx.doi.org/10.3390/70600487 |
| _version_ | 1783356397755301888 |
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| author | Thennarasu, S. Perumal, P. T. |
| author_facet | Thennarasu, S. Perumal, P. T. |
| author_sort | Thennarasu, S. |
| collection | PubMed |
| description | A convenient four-step method for the preparation of the lipophilic vicinal diamine 1,2-diamino-1-phenylheptane is described. Condensation involving octan-2-one, benzaldehyde and ammonia is reported. Regioselective Schmidt rearrangement of 2,6-diphenyl-3-pentyl-piperidin-4-one (1) to 2,7-diphenyl-3-pentyl hexahydrodiazapin-5-one (3) is presented. Hydrolysis of 2,7-diphenyl-3-pentyl hexahydrodiazapin-5-one to 1,2-diamino-1-phenylheptane (4) is also reported for the first time. |
| format | Online Article Text |
| id | pubmed-6146457 |
| institution | National Center for Biotechnology Information |
| language | English |
| publishDate | 2002 |
| publisher | MDPI |
| record_format | MEDLINE/PubMed |
| spelling | pubmed-61464572018-11-19 An Efficient Preparation of 1,2-Diamino-1-phenylheptane Thennarasu, S. Perumal, P. T. Molecules Article A convenient four-step method for the preparation of the lipophilic vicinal diamine 1,2-diamino-1-phenylheptane is described. Condensation involving octan-2-one, benzaldehyde and ammonia is reported. Regioselective Schmidt rearrangement of 2,6-diphenyl-3-pentyl-piperidin-4-one (1) to 2,7-diphenyl-3-pentyl hexahydrodiazapin-5-one (3) is presented. Hydrolysis of 2,7-diphenyl-3-pentyl hexahydrodiazapin-5-one to 1,2-diamino-1-phenylheptane (4) is also reported for the first time. MDPI 2002-06-30 /pmc/articles/PMC6146457/ http://dx.doi.org/10.3390/70600487 Text en © 2002 by MDPI (http://www.mdpi.org). Reproduction is permitted for noncommercial purposes. |
| spellingShingle | Article Thennarasu, S. Perumal, P. T. An Efficient Preparation of 1,2-Diamino-1-phenylheptane |
| title | An Efficient Preparation of 1,2-Diamino-1-phenylheptane |
| title_full | An Efficient Preparation of 1,2-Diamino-1-phenylheptane |
| title_fullStr | An Efficient Preparation of 1,2-Diamino-1-phenylheptane |
| title_full_unstemmed | An Efficient Preparation of 1,2-Diamino-1-phenylheptane |
| title_short | An Efficient Preparation of 1,2-Diamino-1-phenylheptane |
| title_sort | efficient preparation of 1,2-diamino-1-phenylheptane |
| topic | Article |
| url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6146457/ http://dx.doi.org/10.3390/70600487 |
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