Synthesis of Platinum Complexes from N-Benzyl-1,3-Propane-diamine Derivatives, Potential Antineoplastic Agents

This work describes the synthesis of seven new platinum complexes having N-benzyl 1,3-propanediamine derivatives as ligands. They were prepared by the reaction of K(2)[PtCl(4)] with the appropriate ligand in water. These complexes are analogs of cisplatin, and are potential antineoplastic agents.

Detalles Bibliográficos
Autores principales: de Almeida, Mauro Vieira, Fontes, Ana Paula Soares, Berg, Richard Nilton, César, Eloi Teixeira, de Castro Antunes Felício, Emanoel, de Souza Filho, José Dias
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2002
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6146513/
http://dx.doi.org/10.3390/70400405
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author de Almeida, Mauro Vieira
Fontes, Ana Paula Soares
Berg, Richard Nilton
César, Eloi Teixeira
de Castro Antunes Felício, Emanoel
de Souza Filho, José Dias
author_facet de Almeida, Mauro Vieira
Fontes, Ana Paula Soares
Berg, Richard Nilton
César, Eloi Teixeira
de Castro Antunes Felício, Emanoel
de Souza Filho, José Dias
author_sort de Almeida, Mauro Vieira
collection PubMed
description This work describes the synthesis of seven new platinum complexes having N-benzyl 1,3-propanediamine derivatives as ligands. They were prepared by the reaction of K(2)[PtCl(4)] with the appropriate ligand in water. These complexes are analogs of cisplatin, and are potential antineoplastic agents.
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spelling pubmed-61465132018-11-19 Synthesis of Platinum Complexes from N-Benzyl-1,3-Propane-diamine Derivatives, Potential Antineoplastic Agents de Almeida, Mauro Vieira Fontes, Ana Paula Soares Berg, Richard Nilton César, Eloi Teixeira de Castro Antunes Felício, Emanoel de Souza Filho, José Dias Molecules Article This work describes the synthesis of seven new platinum complexes having N-benzyl 1,3-propanediamine derivatives as ligands. They were prepared by the reaction of K(2)[PtCl(4)] with the appropriate ligand in water. These complexes are analogs of cisplatin, and are potential antineoplastic agents. MDPI 2002-04-30 /pmc/articles/PMC6146513/ http://dx.doi.org/10.3390/70400405 Text en © 2002 by MDPI (http://www.mdpi.org). Reproduction is permitted for non commercial purposes.
spellingShingle Article
de Almeida, Mauro Vieira
Fontes, Ana Paula Soares
Berg, Richard Nilton
César, Eloi Teixeira
de Castro Antunes Felício, Emanoel
de Souza Filho, José Dias
Synthesis of Platinum Complexes from N-Benzyl-1,3-Propane-diamine Derivatives, Potential Antineoplastic Agents
title Synthesis of Platinum Complexes from N-Benzyl-1,3-Propane-diamine Derivatives, Potential Antineoplastic Agents
title_full Synthesis of Platinum Complexes from N-Benzyl-1,3-Propane-diamine Derivatives, Potential Antineoplastic Agents
title_fullStr Synthesis of Platinum Complexes from N-Benzyl-1,3-Propane-diamine Derivatives, Potential Antineoplastic Agents
title_full_unstemmed Synthesis of Platinum Complexes from N-Benzyl-1,3-Propane-diamine Derivatives, Potential Antineoplastic Agents
title_short Synthesis of Platinum Complexes from N-Benzyl-1,3-Propane-diamine Derivatives, Potential Antineoplastic Agents
title_sort synthesis of platinum complexes from n-benzyl-1,3-propane-diamine derivatives, potential antineoplastic agents
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6146513/
http://dx.doi.org/10.3390/70400405
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