Novel Cytotoxic Oxopyridoindolizines: iso-Propyl-7,8,9-tri-chloro-6,7,8,9-tetrahydro-5-oxopyrido[2,3-a]-indolizine-10-carboxylates (OPIC)

A series of eight new alkyl-7,8,9-trichloro-6,7,8,9-tetrahydro-5-oxopyrido[2,3-a]-indolizine-10-carboxylates (OPIC), analogues of camptothecin (CPT), were prepared in a one-pot reaction of 2,2'-bipyridine-3,3'-dicarboxylic acid (BPA) with a mixture of thionyl chloride/chlorine, followed by...

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Detalles Bibliográficos
Autores principales: Zunino, Franco, Kotchevar, Ann T., Waring, Michael, Daoudi, Maria, Larbi, Najib Ben, Mimouni, Mostafa, Sam, Najat, Zahidi, Assou, Ben-Hadda, Taibi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2002
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6146537/
http://dx.doi.org/10.3390/70800628

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6146537/
http://dx.doi.org/10.3390/70800628

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