High-Definition Analysis of Host Protein Stability during Human Cytomegalovirus Infection Reveals Antiviral Factors and Viral Evasion Mechanisms

Human cytomegalovirus (HCMV) is an important pathogen with multiple immune evasion strategies, including virally facilitated degradation of host antiviral restriction factors. Here, we describe a multiplexed approach to discover proteins with innate immune function on the basis of active degradation...

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Detalles Bibliográficos
Autores principales: Nightingale, Katie, Lin, Kai-Min, Ravenhill, Benjamin J., Davies, Colin, Nobre, Luis, Fielding, Ceri A., Ruckova, Eva, Fletcher-Etherington, Alice, Soday, Lior, Nichols, Hester, Sugrue, Daniel, Wang, Eddie C.Y., Moreno, Pablo, Umrania, Yagnesh, Huttlin, Edward L., Antrobus, Robin, Davison, Andrew J., Wilkinson, Gavin W.G., Stanton, Richard J., Tomasec, Peter, Weekes, Michael P.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cell Press 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6146656/
https://www.ncbi.nlm.nih.gov/pubmed/30122656
http://dx.doi.org/10.1016/j.chom.2018.07.011

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