An Improved Three Step Synthesis of (-)-3β-Hydroxycarvone from (-)-Carvone

(-)-Carvone (3) has been efficiently transformed into (-)-3β-hydroxycarvone (1), which is expected to be a useful synthon or chiral template in the synthesis of natural molecules. This short and efficient synthesis of compound 1 involves regioselective and stereoselective α-hydroxylation of carvone...

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Detalles Bibliográficos
Autores principales: dos Santos, Reginaldo B., Brocksom, Timothy J., Zanotto, Paulo R., Brocksom, Ursula
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2002
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6146741/
http://dx.doi.org/10.3390/70200129
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author dos Santos, Reginaldo B.
Brocksom, Timothy J.
Zanotto, Paulo R.
Brocksom, Ursula
author_facet dos Santos, Reginaldo B.
Brocksom, Timothy J.
Zanotto, Paulo R.
Brocksom, Ursula
author_sort dos Santos, Reginaldo B.
collection PubMed
description (-)-Carvone (3) has been efficiently transformed into (-)-3β-hydroxycarvone (1), which is expected to be a useful synthon or chiral template in the synthesis of natural molecules. This short and efficient synthesis of compound 1 involves regioselective and stereoselective α-hydroxylation of carvone via the trimethylsilyl-dienyl-ether derivative.
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spelling pubmed-61467412018-11-19 An Improved Three Step Synthesis of (-)-3β-Hydroxycarvone from (-)-Carvone dos Santos, Reginaldo B. Brocksom, Timothy J. Zanotto, Paulo R. Brocksom, Ursula Molecules Article (-)-Carvone (3) has been efficiently transformed into (-)-3β-hydroxycarvone (1), which is expected to be a useful synthon or chiral template in the synthesis of natural molecules. This short and efficient synthesis of compound 1 involves regioselective and stereoselective α-hydroxylation of carvone via the trimethylsilyl-dienyl-ether derivative. MDPI 2002-02-28 /pmc/articles/PMC6146741/ http://dx.doi.org/10.3390/70200129 Text en © 2002 by MDPI (http://www.mdpi.org). Reproduction is permitted for non commercial purposes.
spellingShingle Article
dos Santos, Reginaldo B.
Brocksom, Timothy J.
Zanotto, Paulo R.
Brocksom, Ursula
An Improved Three Step Synthesis of (-)-3β-Hydroxycarvone from (-)-Carvone
title An Improved Three Step Synthesis of (-)-3β-Hydroxycarvone from (-)-Carvone
title_full An Improved Three Step Synthesis of (-)-3β-Hydroxycarvone from (-)-Carvone
title_fullStr An Improved Three Step Synthesis of (-)-3β-Hydroxycarvone from (-)-Carvone
title_full_unstemmed An Improved Three Step Synthesis of (-)-3β-Hydroxycarvone from (-)-Carvone
title_short An Improved Three Step Synthesis of (-)-3β-Hydroxycarvone from (-)-Carvone
title_sort improved three step synthesis of (-)-3β-hydroxycarvone from (-)-carvone
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6146741/
http://dx.doi.org/10.3390/70200129
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