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HSCs-derived COMP drives hepatocellular carcinoma progression by activating MEK/ERK and PI3K/AKT signaling pathways

BACKGROUND: Cartilage oligomeric matrix protein (COMP) is known to promote fibrosis in skin, lung and liver. Emerging evidence shows that COMP plays critical roles in tumor development, including breast cancer, colon cancer and hepatocellular carcinoma (HCC). Nevertheless, the role of COMP in HCC pr...

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Detalles Bibliográficos
Autores principales:	Li, Qing, Wang, Cong, Wang, Yufeng, Sun, Liankang, Liu, Zhikui, Wang, Liang, Song, Tao, Yao, Yingmin, Liu, Qingguang, Tu, Kangsheng
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2018
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6146743/ https://www.ncbi.nlm.nih.gov/pubmed/30231922 http://dx.doi.org/10.1186/s13046-018-0908-y

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