Synthesis and Biological Evaluation of Some New Coumarin Derivatives

Pyrimidino[5`,4`-6,5]-,pyridino[3`,2`-6,5]- and pyrrolo[3`,2`-5,6]4H-pyrano-[3,2-c][1]benzopyran-6-one derivatives (5-7 and 10) could be obtained via reaction of 2-amino-4-(p-bromophenyl)-3-cyano(carboethoxy)-4H,5H-pyrano[3,2-c][1]benzopyran-5-ones (3a,b)with a variety of reagents. Alkylation of (3b...

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Autores principales: Al-Haiza, M.A., Mostafa, M.S., El-Kady, M.Y.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2003
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6146840/
http://dx.doi.org/10.3390/80200275
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author Al-Haiza, M.A.
Mostafa, M.S.
El-Kady, M.Y.
author_facet Al-Haiza, M.A.
Mostafa, M.S.
El-Kady, M.Y.
author_sort Al-Haiza, M.A.
collection PubMed
description Pyrimidino[5`,4`-6,5]-,pyridino[3`,2`-6,5]- and pyrrolo[3`,2`-5,6]4H-pyrano-[3,2-c][1]benzopyran-6-one derivatives (5-7 and 10) could be obtained via reaction of 2-amino-4-(p-bromophenyl)-3-cyano(carboethoxy)-4H,5H-pyrano[3,2-c][1]benzopyran-5-ones (3a,b)with a variety of reagents. Alkylation of (3b) with either 2-furoyl chloride or chloroacetyl chloride gave the 2-N-substituted derivatives (9a,b). Benzofurano[3,2-b]4H-pyran derivative (12) was also prepared. The antimicrobial activity of the prepared compounds was tested.
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spelling pubmed-61468402018-11-19 Synthesis and Biological Evaluation of Some New Coumarin Derivatives Al-Haiza, M.A. Mostafa, M.S. El-Kady, M.Y. Molecules Article Pyrimidino[5`,4`-6,5]-,pyridino[3`,2`-6,5]- and pyrrolo[3`,2`-5,6]4H-pyrano-[3,2-c][1]benzopyran-6-one derivatives (5-7 and 10) could be obtained via reaction of 2-amino-4-(p-bromophenyl)-3-cyano(carboethoxy)-4H,5H-pyrano[3,2-c][1]benzopyran-5-ones (3a,b)with a variety of reagents. Alkylation of (3b) with either 2-furoyl chloride or chloroacetyl chloride gave the 2-N-substituted derivatives (9a,b). Benzofurano[3,2-b]4H-pyran derivative (12) was also prepared. The antimicrobial activity of the prepared compounds was tested. MDPI 2003-02-28 /pmc/articles/PMC6146840/ http://dx.doi.org/10.3390/80200275 Text en © 2003 by MDPI (http://www.mdpi.org). Reproduction is permitted for noncommercial purposes.
spellingShingle Article
Al-Haiza, M.A.
Mostafa, M.S.
El-Kady, M.Y.
Synthesis and Biological Evaluation of Some New Coumarin Derivatives
title Synthesis and Biological Evaluation of Some New Coumarin Derivatives
title_full Synthesis and Biological Evaluation of Some New Coumarin Derivatives
title_fullStr Synthesis and Biological Evaluation of Some New Coumarin Derivatives
title_full_unstemmed Synthesis and Biological Evaluation of Some New Coumarin Derivatives
title_short Synthesis and Biological Evaluation of Some New Coumarin Derivatives
title_sort synthesis and biological evaluation of some new coumarin derivatives
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6146840/
http://dx.doi.org/10.3390/80200275
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AT elkadymy synthesisandbiologicalevaluationofsomenewcoumarinderivatives

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