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Synthesis and Biological Evaluation of New 4,5-Disubstituted-Thiazolyl Amides, Derivatives of 4-Hydroxy-Piperidine or of 4-N-Methyl Piperazine

4,5-disubstituted-thizolyl amides, derivatives of 4-hydroxy-piperidine and of 4-N-methyl piperazine, were synthesized and tested as anti-inflammatory agents. Log P values were theoretically calculated and experimentally determined. These compounds were tested for antioxidant activity, as hydroxyl ra...

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Autores principales: Geronikaki, A., Hadjipavlou-Litina, D., Chatziopoulos, C., Soloupis, G.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2003
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6146878/
http://dx.doi.org/10.3390/80600472
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author Geronikaki, A.
Hadjipavlou-Litina, D.
Chatziopoulos, C.
Soloupis, G.
author_facet Geronikaki, A.
Hadjipavlou-Litina, D.
Chatziopoulos, C.
Soloupis, G.
author_sort Geronikaki, A.
collection PubMed
description 4,5-disubstituted-thizolyl amides, derivatives of 4-hydroxy-piperidine and of 4-N-methyl piperazine, were synthesized and tested as anti-inflammatory agents. Log P values were theoretically calculated and experimentally determined. These compounds were tested for antioxidant activity, as hydroxyl radical scavengers and for their ability to in­teract with stable 1,1-diphenyl-2-picryl hydrazyl free radical (DPPH). The effect of the syn­thesized compounds on inflammation, using the carrageenin induced mice paw edema mo­del was studied. Both anti-inflammatory and antioxidant activities depended on some structural characteristics of the synthesized compounds.
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spelling pubmed-61468782018-11-19 Synthesis and Biological Evaluation of New 4,5-Disubstituted-Thiazolyl Amides, Derivatives of 4-Hydroxy-Piperidine or of 4-N-Methyl Piperazine Geronikaki, A. Hadjipavlou-Litina, D. Chatziopoulos, C. Soloupis, G. Molecules Article 4,5-disubstituted-thizolyl amides, derivatives of 4-hydroxy-piperidine and of 4-N-methyl piperazine, were synthesized and tested as anti-inflammatory agents. Log P values were theoretically calculated and experimentally determined. These compounds were tested for antioxidant activity, as hydroxyl radical scavengers and for their ability to in­teract with stable 1,1-diphenyl-2-picryl hydrazyl free radical (DPPH). The effect of the syn­thesized compounds on inflammation, using the carrageenin induced mice paw edema mo­del was studied. Both anti-inflammatory and antioxidant activities depended on some structural characteristics of the synthesized compounds. MDPI 2003-06-30 /pmc/articles/PMC6146878/ http://dx.doi.org/10.3390/80600472 Text en © 2003 by MDPI (http://www.mdpi.org). Reproduction is permitted for noncommercial purposes.
spellingShingle Article
Geronikaki, A.
Hadjipavlou-Litina, D.
Chatziopoulos, C.
Soloupis, G.
Synthesis and Biological Evaluation of New 4,5-Disubstituted-Thiazolyl Amides, Derivatives of 4-Hydroxy-Piperidine or of 4-N-Methyl Piperazine
title Synthesis and Biological Evaluation of New 4,5-Disubstituted-Thiazolyl Amides, Derivatives of 4-Hydroxy-Piperidine or of 4-N-Methyl Piperazine
title_full Synthesis and Biological Evaluation of New 4,5-Disubstituted-Thiazolyl Amides, Derivatives of 4-Hydroxy-Piperidine or of 4-N-Methyl Piperazine
title_fullStr Synthesis and Biological Evaluation of New 4,5-Disubstituted-Thiazolyl Amides, Derivatives of 4-Hydroxy-Piperidine or of 4-N-Methyl Piperazine
title_full_unstemmed Synthesis and Biological Evaluation of New 4,5-Disubstituted-Thiazolyl Amides, Derivatives of 4-Hydroxy-Piperidine or of 4-N-Methyl Piperazine
title_short Synthesis and Biological Evaluation of New 4,5-Disubstituted-Thiazolyl Amides, Derivatives of 4-Hydroxy-Piperidine or of 4-N-Methyl Piperazine
title_sort synthesis and biological evaluation of new 4,5-disubstituted-thiazolyl amides, derivatives of 4-hydroxy-piperidine or of 4-n-methyl piperazine
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6146878/
http://dx.doi.org/10.3390/80600472
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