Microwave-Assisted Synthesis of Some 3,5-Arylated 2-Pyrazolines

Condensation of 2-acetylnaphthalene with benzaldehydes under microwave irradiation affords chalcones which undergo facile and clean cyclizations with hydrazines RNHNH(2) (R= H, Ph, Ac) to afford 3,5-arylated 2-pyrazolines in quantitative yields, also under microwave irradiation and in the presence o...

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Autores principales: Azarifar, Davood, Ghasemnejad, Hassan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2003
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6146882/
http://dx.doi.org/10.3390/80800642
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author Azarifar, Davood
Ghasemnejad, Hassan
author_facet Azarifar, Davood
Ghasemnejad, Hassan
author_sort Azarifar, Davood
collection PubMed
description Condensation of 2-acetylnaphthalene with benzaldehydes under microwave irradiation affords chalcones which undergo facile and clean cyclizations with hydrazines RNHNH(2) (R= H, Ph, Ac) to afford 3,5-arylated 2-pyrazolines in quantitative yields, also under microwave irradiation and in the presence of dry AcOH as cyclizing agent. The results obtained indicate that, unlike classical heating, microwave irradiation results in higher yields, shorter reaction times (2-12 min.) and cleaner reactions.
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spelling pubmed-61468822018-11-19 Microwave-Assisted Synthesis of Some 3,5-Arylated 2-Pyrazolines Azarifar, Davood Ghasemnejad, Hassan Molecules Article Condensation of 2-acetylnaphthalene with benzaldehydes under microwave irradiation affords chalcones which undergo facile and clean cyclizations with hydrazines RNHNH(2) (R= H, Ph, Ac) to afford 3,5-arylated 2-pyrazolines in quantitative yields, also under microwave irradiation and in the presence of dry AcOH as cyclizing agent. The results obtained indicate that, unlike classical heating, microwave irradiation results in higher yields, shorter reaction times (2-12 min.) and cleaner reactions. MDPI 2003-07-31 /pmc/articles/PMC6146882/ http://dx.doi.org/10.3390/80800642 Text en © 2003 by MDPI (http://www.mdpi.org). Reproduction is permitted for noncommercial purposes.
spellingShingle Article
Azarifar, Davood
Ghasemnejad, Hassan
Microwave-Assisted Synthesis of Some 3,5-Arylated 2-Pyrazolines
title Microwave-Assisted Synthesis of Some 3,5-Arylated 2-Pyrazolines
title_full Microwave-Assisted Synthesis of Some 3,5-Arylated 2-Pyrazolines
title_fullStr Microwave-Assisted Synthesis of Some 3,5-Arylated 2-Pyrazolines
title_full_unstemmed Microwave-Assisted Synthesis of Some 3,5-Arylated 2-Pyrazolines
title_short Microwave-Assisted Synthesis of Some 3,5-Arylated 2-Pyrazolines
title_sort microwave-assisted synthesis of some 3,5-arylated 2-pyrazolines
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6146882/
http://dx.doi.org/10.3390/80800642
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AT ghasemnejadhassan microwaveassistedsynthesisofsome35arylated2pyrazolines

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