The Ring Transformation of 3-Methyl-5-nitropyrimidin-4(3H)-one

3-Methyl-5-nitropyrimidin-4(3H)-one readily reacts with carbonyl compounds to produce three kinds of ring transformations. The nitropyrimidinone behaves as the synthetic equivalent of activated diformylamine affording 3,5-difunctionalized 4-pyridones, 4,5-disubstituted pyrimidines and functionalized...

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Autores principales: Nishiwaki, Nagatoshi, Tamura, Mina, Hori, Kazushige, Tohda, Yasuo, Ariga, Masahiro
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2003
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6146944/
http://dx.doi.org/10.3390/80600500
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author Nishiwaki, Nagatoshi
Tamura, Mina
Hori, Kazushige
Tohda, Yasuo
Ariga, Masahiro
author_facet Nishiwaki, Nagatoshi
Tamura, Mina
Hori, Kazushige
Tohda, Yasuo
Ariga, Masahiro
author_sort Nishiwaki, Nagatoshi
collection PubMed
description 3-Methyl-5-nitropyrimidin-4(3H)-one readily reacts with carbonyl compounds to produce three kinds of ring transformations. The nitropyrimidinone behaves as the synthetic equivalent of activated diformylamine affording 3,5-difunctionalized 4-pyridones, 4,5-disubstituted pyrimidines and functionalized 4-aminopyridines. It also behaves like α-nitro-formylacetic acid to give 5,6-disubstituted 3-nitro-2-pyridones.
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spelling pubmed-61469442018-11-19 The Ring Transformation of 3-Methyl-5-nitropyrimidin-4(3H)-one Nishiwaki, Nagatoshi Tamura, Mina Hori, Kazushige Tohda, Yasuo Ariga, Masahiro Molecules Article 3-Methyl-5-nitropyrimidin-4(3H)-one readily reacts with carbonyl compounds to produce three kinds of ring transformations. The nitropyrimidinone behaves as the synthetic equivalent of activated diformylamine affording 3,5-difunctionalized 4-pyridones, 4,5-disubstituted pyrimidines and functionalized 4-aminopyridines. It also behaves like α-nitro-formylacetic acid to give 5,6-disubstituted 3-nitro-2-pyridones. MDPI 2003-06-30 /pmc/articles/PMC6146944/ http://dx.doi.org/10.3390/80600500 Text en © 2003 by MDPI (http://www.mdpi.org). Reproduction is permitted for noncommercial purposes.
spellingShingle Article
Nishiwaki, Nagatoshi
Tamura, Mina
Hori, Kazushige
Tohda, Yasuo
Ariga, Masahiro
The Ring Transformation of 3-Methyl-5-nitropyrimidin-4(3H)-one
title The Ring Transformation of 3-Methyl-5-nitropyrimidin-4(3H)-one
title_full The Ring Transformation of 3-Methyl-5-nitropyrimidin-4(3H)-one
title_fullStr The Ring Transformation of 3-Methyl-5-nitropyrimidin-4(3H)-one
title_full_unstemmed The Ring Transformation of 3-Methyl-5-nitropyrimidin-4(3H)-one
title_short The Ring Transformation of 3-Methyl-5-nitropyrimidin-4(3H)-one
title_sort ring transformation of 3-methyl-5-nitropyrimidin-4(3h)-one
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6146944/
http://dx.doi.org/10.3390/80600500
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