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Synthesis of Plasmepsin II Inhibitors – Potential Antimalarial Agents
A new series of plasmepsin II (PM II) inhibitors has been prepared based on 4-aminopiperidine-tert-butyl-carbamate (1). These compounds might be useful as antimalarial drugs acting via a new mechanism, and therefore be less susceptible to parasite resistance now often observed with current antimalar...
| Autores principales: | , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
MDPI
2003
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6146960/ http://dx.doi.org/10.3390/80700556 |
| _version_ | 1783356492575932416 |
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| author | Mueller, Reto Huerzeler, Marianne Boss, Christoph |
| author_facet | Mueller, Reto Huerzeler, Marianne Boss, Christoph |
| author_sort | Mueller, Reto |
| collection | PubMed |
| description | A new series of plasmepsin II (PM II) inhibitors has been prepared based on 4-aminopiperidine-tert-butyl-carbamate (1). These compounds might be useful as antimalarial drugs acting via a new mechanism, and therefore be less susceptible to parasite resistance now often observed with current antimalarial therapies. Some of the final compounds prepared exhibited encouraging inhibitory activity towards PM II. |
| format | Online Article Text |
| id | pubmed-6146960 |
| institution | National Center for Biotechnology Information |
| language | English |
| publishDate | 2003 |
| publisher | MDPI |
| record_format | MEDLINE/PubMed |
| spelling | pubmed-61469602018-11-19 Synthesis of Plasmepsin II Inhibitors – Potential Antimalarial Agents Mueller, Reto Huerzeler, Marianne Boss, Christoph Molecules Article A new series of plasmepsin II (PM II) inhibitors has been prepared based on 4-aminopiperidine-tert-butyl-carbamate (1). These compounds might be useful as antimalarial drugs acting via a new mechanism, and therefore be less susceptible to parasite resistance now often observed with current antimalarial therapies. Some of the final compounds prepared exhibited encouraging inhibitory activity towards PM II. MDPI 2003-07-15 /pmc/articles/PMC6146960/ http://dx.doi.org/10.3390/80700556 Text en © 2003 by MDPI (http://www.mdpi.org). Reproduction is permitted for noncommercial purposes. |
| spellingShingle | Article Mueller, Reto Huerzeler, Marianne Boss, Christoph Synthesis of Plasmepsin II Inhibitors – Potential Antimalarial Agents |
| title | Synthesis of Plasmepsin II Inhibitors – Potential Antimalarial Agents |
| title_full | Synthesis of Plasmepsin II Inhibitors – Potential Antimalarial Agents |
| title_fullStr | Synthesis of Plasmepsin II Inhibitors – Potential Antimalarial Agents |
| title_full_unstemmed | Synthesis of Plasmepsin II Inhibitors – Potential Antimalarial Agents |
| title_short | Synthesis of Plasmepsin II Inhibitors – Potential Antimalarial Agents |
| title_sort | synthesis of plasmepsin ii inhibitors – potential antimalarial agents |
| topic | Article |
| url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6146960/ http://dx.doi.org/10.3390/80700556 |
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