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Oxa‐Michael Addition to α,β‐Unsaturated Nitriles: An Expedient Route to γ‐Amino Alcohols and Derivatives

Water addition to α,β‐unsaturated nitriles would give facile access to the β‐hydroxy‐nitriles, which in turn can be hydrogenated to the γ‐amino alcohols. We have previously shown that alcohols readily add in 1,4‐fashion to these substrates using Milstein's Ru(PNN) pincer complex as catalyst. Ho...

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Detalles Bibliográficos
Autores principales:	Guo, Beibei, Zijlstra, Douwe S., de Vries, Johannes G., Otten, Edwin
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	John Wiley and Sons Inc. 2018
Materias:	Full Papers
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6147005/ https://www.ncbi.nlm.nih.gov/pubmed/30263082 http://dx.doi.org/10.1002/cctc.201800509

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