Novel 4-Aroyl-3-alkoxy-2(5H)-furanones as Precursors for the Preparation of Furo[3,4-b][1,4]-diazepine Ring System(‡)

A general synthesis of tetronic acid derivatives, namely 4-aroyl-3-alkoxy-2(5H)-furanones, is achieved via the treatment of an anhydrous dimethylformamide (DMF) solution of 4-aroyl-3-hydroxy-2(5H)-furanones with 1,8-diazabicyclo[5.4.0]undec-7-ene (DBU) as base at -10-0°C, followed by the addition of...

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Autores principales: Zimmer, Hans, Librera, Christian P., Hausner, Sven, Bauer, Jeanette, Amer, Adel
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2003
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6147071/
http://dx.doi.org/10.3390/81000735
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author Zimmer, Hans
Librera, Christian P.
Hausner, Sven
Bauer, Jeanette
Amer, Adel
author_facet Zimmer, Hans
Librera, Christian P.
Hausner, Sven
Bauer, Jeanette
Amer, Adel
author_sort Zimmer, Hans
collection PubMed
description A general synthesis of tetronic acid derivatives, namely 4-aroyl-3-alkoxy-2(5H)-furanones, is achieved via the treatment of an anhydrous dimethylformamide (DMF) solution of 4-aroyl-3-hydroxy-2(5H)-furanones with 1,8-diazabicyclo[5.4.0]undec-7-ene (DBU) as base at -10-0°C, followed by the addition of alkyl iodide. Their structural assignments are based on spectroscopic data and confirmed by X-ray crystallography. These furanones were used as starting materials for the preparation of furodiazepines.
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spelling pubmed-61470712018-11-19 Novel 4-Aroyl-3-alkoxy-2(5H)-furanones as Precursors for the Preparation of Furo[3,4-b][1,4]-diazepine Ring System(‡) Zimmer, Hans Librera, Christian P. Hausner, Sven Bauer, Jeanette Amer, Adel Molecules Article A general synthesis of tetronic acid derivatives, namely 4-aroyl-3-alkoxy-2(5H)-furanones, is achieved via the treatment of an anhydrous dimethylformamide (DMF) solution of 4-aroyl-3-hydroxy-2(5H)-furanones with 1,8-diazabicyclo[5.4.0]undec-7-ene (DBU) as base at -10-0°C, followed by the addition of alkyl iodide. Their structural assignments are based on spectroscopic data and confirmed by X-ray crystallography. These furanones were used as starting materials for the preparation of furodiazepines. MDPI 2003-10-31 /pmc/articles/PMC6147071/ http://dx.doi.org/10.3390/81000735 Text en © 2003 (http://www.mdpi.org). Reproduction is permitted for noncommercial purposes.
spellingShingle Article
Zimmer, Hans
Librera, Christian P.
Hausner, Sven
Bauer, Jeanette
Amer, Adel
Novel 4-Aroyl-3-alkoxy-2(5H)-furanones as Precursors for the Preparation of Furo[3,4-b][1,4]-diazepine Ring System(‡)
title Novel 4-Aroyl-3-alkoxy-2(5H)-furanones as Precursors for the Preparation of Furo[3,4-b][1,4]-diazepine Ring System(‡)
title_full Novel 4-Aroyl-3-alkoxy-2(5H)-furanones as Precursors for the Preparation of Furo[3,4-b][1,4]-diazepine Ring System(‡)
title_fullStr Novel 4-Aroyl-3-alkoxy-2(5H)-furanones as Precursors for the Preparation of Furo[3,4-b][1,4]-diazepine Ring System(‡)
title_full_unstemmed Novel 4-Aroyl-3-alkoxy-2(5H)-furanones as Precursors for the Preparation of Furo[3,4-b][1,4]-diazepine Ring System(‡)
title_short Novel 4-Aroyl-3-alkoxy-2(5H)-furanones as Precursors for the Preparation of Furo[3,4-b][1,4]-diazepine Ring System(‡)
title_sort novel 4-aroyl-3-alkoxy-2(5h)-furanones as precursors for the preparation of furo[3,4-b][1,4]-diazepine ring system(‡)
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6147071/
http://dx.doi.org/10.3390/81000735
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