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Reprogramming towards endothelial cells for vascular regeneration
Endothelial damage and dysfunction are implicated in cardiovascular pathological changes and the development of vascular diseases. In view of the fact that the spontaneous endothelial cell (EC) regeneration is a slow and insufficient process, it is of great significance to explore alternative cell s...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Chongqing Medical University
2016
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6147164/ https://www.ncbi.nlm.nih.gov/pubmed/30258888 http://dx.doi.org/10.1016/j.gendis.2016.02.003 |
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author | Hong, Xuechong Le Bras, Alexandra Margariti, Andriana Xu, Qingbo |
author_facet | Hong, Xuechong Le Bras, Alexandra Margariti, Andriana Xu, Qingbo |
author_sort | Hong, Xuechong |
collection | PubMed |
description | Endothelial damage and dysfunction are implicated in cardiovascular pathological changes and the development of vascular diseases. In view of the fact that the spontaneous endothelial cell (EC) regeneration is a slow and insufficient process, it is of great significance to explore alternative cell sources capable of generating functional ECs to repair damaged endothelium. Indeed, recent achievements of cell reprogramming to convert somatic cells to other cell types provide new powerful approaches to study endothelial regeneration. Based on progress in the research field, the present review aims to summarize the strategies and mechanisms of generating endothelial cells through reprogramming from somatic cells, and to examine what this means for the potential application of cell therapy in the clinic. |
format | Online Article Text |
id | pubmed-6147164 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2016 |
publisher | Chongqing Medical University |
record_format | MEDLINE/PubMed |
spelling | pubmed-61471642018-09-26 Reprogramming towards endothelial cells for vascular regeneration Hong, Xuechong Le Bras, Alexandra Margariti, Andriana Xu, Qingbo Genes Dis Article Endothelial damage and dysfunction are implicated in cardiovascular pathological changes and the development of vascular diseases. In view of the fact that the spontaneous endothelial cell (EC) regeneration is a slow and insufficient process, it is of great significance to explore alternative cell sources capable of generating functional ECs to repair damaged endothelium. Indeed, recent achievements of cell reprogramming to convert somatic cells to other cell types provide new powerful approaches to study endothelial regeneration. Based on progress in the research field, the present review aims to summarize the strategies and mechanisms of generating endothelial cells through reprogramming from somatic cells, and to examine what this means for the potential application of cell therapy in the clinic. Chongqing Medical University 2016-02-27 /pmc/articles/PMC6147164/ /pubmed/30258888 http://dx.doi.org/10.1016/j.gendis.2016.02.003 Text en Copyright © 2016, Chongqing Medical University. Production and hosting by Elsevier B.V. http://creativecommons.org/licenses/by-nc-nd/4.0/ This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/). |
spellingShingle | Article Hong, Xuechong Le Bras, Alexandra Margariti, Andriana Xu, Qingbo Reprogramming towards endothelial cells for vascular regeneration |
title | Reprogramming towards endothelial cells for vascular regeneration |
title_full | Reprogramming towards endothelial cells for vascular regeneration |
title_fullStr | Reprogramming towards endothelial cells for vascular regeneration |
title_full_unstemmed | Reprogramming towards endothelial cells for vascular regeneration |
title_short | Reprogramming towards endothelial cells for vascular regeneration |
title_sort | reprogramming towards endothelial cells for vascular regeneration |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6147164/ https://www.ncbi.nlm.nih.gov/pubmed/30258888 http://dx.doi.org/10.1016/j.gendis.2016.02.003 |
work_keys_str_mv | AT hongxuechong reprogrammingtowardsendothelialcellsforvascularregeneration AT lebrasalexandra reprogrammingtowardsendothelialcellsforvascularregeneration AT margaritiandriana reprogrammingtowardsendothelialcellsforvascularregeneration AT xuqingbo reprogrammingtowardsendothelialcellsforvascularregeneration |