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Reprogramming towards endothelial cells for vascular regeneration

Endothelial damage and dysfunction are implicated in cardiovascular pathological changes and the development of vascular diseases. In view of the fact that the spontaneous endothelial cell (EC) regeneration is a slow and insufficient process, it is of great significance to explore alternative cell s...

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Detalles Bibliográficos
Autores principales: Hong, Xuechong, Le Bras, Alexandra, Margariti, Andriana, Xu, Qingbo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Chongqing Medical University 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6147164/
https://www.ncbi.nlm.nih.gov/pubmed/30258888
http://dx.doi.org/10.1016/j.gendis.2016.02.003
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author Hong, Xuechong
Le Bras, Alexandra
Margariti, Andriana
Xu, Qingbo
author_facet Hong, Xuechong
Le Bras, Alexandra
Margariti, Andriana
Xu, Qingbo
author_sort Hong, Xuechong
collection PubMed
description Endothelial damage and dysfunction are implicated in cardiovascular pathological changes and the development of vascular diseases. In view of the fact that the spontaneous endothelial cell (EC) regeneration is a slow and insufficient process, it is of great significance to explore alternative cell sources capable of generating functional ECs to repair damaged endothelium. Indeed, recent achievements of cell reprogramming to convert somatic cells to other cell types provide new powerful approaches to study endothelial regeneration. Based on progress in the research field, the present review aims to summarize the strategies and mechanisms of generating endothelial cells through reprogramming from somatic cells, and to examine what this means for the potential application of cell therapy in the clinic.
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spelling pubmed-61471642018-09-26 Reprogramming towards endothelial cells for vascular regeneration Hong, Xuechong Le Bras, Alexandra Margariti, Andriana Xu, Qingbo Genes Dis Article Endothelial damage and dysfunction are implicated in cardiovascular pathological changes and the development of vascular diseases. In view of the fact that the spontaneous endothelial cell (EC) regeneration is a slow and insufficient process, it is of great significance to explore alternative cell sources capable of generating functional ECs to repair damaged endothelium. Indeed, recent achievements of cell reprogramming to convert somatic cells to other cell types provide new powerful approaches to study endothelial regeneration. Based on progress in the research field, the present review aims to summarize the strategies and mechanisms of generating endothelial cells through reprogramming from somatic cells, and to examine what this means for the potential application of cell therapy in the clinic. Chongqing Medical University 2016-02-27 /pmc/articles/PMC6147164/ /pubmed/30258888 http://dx.doi.org/10.1016/j.gendis.2016.02.003 Text en Copyright © 2016, Chongqing Medical University. Production and hosting by Elsevier B.V. http://creativecommons.org/licenses/by-nc-nd/4.0/ This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Article
Hong, Xuechong
Le Bras, Alexandra
Margariti, Andriana
Xu, Qingbo
Reprogramming towards endothelial cells for vascular regeneration
title Reprogramming towards endothelial cells for vascular regeneration
title_full Reprogramming towards endothelial cells for vascular regeneration
title_fullStr Reprogramming towards endothelial cells for vascular regeneration
title_full_unstemmed Reprogramming towards endothelial cells for vascular regeneration
title_short Reprogramming towards endothelial cells for vascular regeneration
title_sort reprogramming towards endothelial cells for vascular regeneration
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6147164/
https://www.ncbi.nlm.nih.gov/pubmed/30258888
http://dx.doi.org/10.1016/j.gendis.2016.02.003
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